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Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity
นักวิจัย : Thakur, R K , Mishra, Akansha , Ramakrishna, K K G , Mahar, Rohit , Shukla, S K , Srivastava, A K , Tripathi, R P
คำค้น : Pyrimidine Nucleosides , Triazoles , Azido Sugars , α-glucosidase
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Tetrahedron, 2014, 70(45), 8462–8473 , http://hdl.handle.net/123456789/1450
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI communication No. 8805
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A series of novel nucleoside analogues having dual bases (pyrimidine and triazole) and sugars have been synthesized by CuAAC reaction of azido sugars with propynylated pyrimidines. These compounds were evaluated for their in vitro α-glucosidase inhibitory activity. In this series, compounds 4b, 4d, 8a, 8b, 8c, 8e, 8g, 8h and 8i exhibited very good inhibition of α-glucosidase enzyme. Nucleoside analogues 8a, 4b, 8h and 8c displayed 47.4%, 41.8%, 39.4% and 34.6% inhibition respectively, comparable to the standard drug acarbose (53.4%).

บรรณานุกรม :
Thakur, R K , Mishra, Akansha , Ramakrishna, K K G , Mahar, Rohit , Shukla, S K , Srivastava, A K , Tripathi, R P . (2557). Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity.
    : Central Drug Research Institute (CDRI), India.
Thakur, R K , Mishra, Akansha , Ramakrishna, K K G , Mahar, Rohit , Shukla, S K , Srivastava, A K , Tripathi, R P . 2557. "Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity".
    : Central Drug Research Institute (CDRI), India.
Thakur, R K , Mishra, Akansha , Ramakrishna, K K G , Mahar, Rohit , Shukla, S K , Srivastava, A K , Tripathi, R P . "Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Thakur, R K , Mishra, Akansha , Ramakrishna, K K G , Mahar, Rohit , Shukla, S K , Srivastava, A K , Tripathi, R P . Synthesis of novel pyrimidine nucleoside analogues owning multiple bases/sugars and their glycosidase inhibitory activity. : Central Drug Research Institute (CDRI), India; 2557.