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Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents
นักวิจัย : Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P
คำค้น : Antimalarial agent , Phenyl sulfonamides , Diarylureides , Plasmodium falciparum
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : ACS Medicinal Chemistry Letters, 2014, 5 (8), 878–883 , http://hdl.handle.net/123456789/1442
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI communication No. 8709
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A new series of C- linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds screened the C- linked phenyl butenonyl glycosides bearing sulfonamidyl moiety (5a) and ureidyl moiety in the phenyl ring (7d and 8c) showed promising antimalarial activities against both 3D7 and K1 strains with IC50 values in µM range and low cytotoxicity offering new HITS for further exploration

บรรณานุกรม :
Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . (2557). Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents.
    : Central Drug Research Institute (CDRI), India.
Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . 2557. "Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents".
    : Central Drug Research Institute (CDRI), India.
Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . "Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Ramakrishna, K K G , Gunjan, Sarika , Shukla, A K , Pasam, V R , Balaramnavar, V M , Sharma, Abhisheak , Jaiswal, Swati , Lal, Jawahar , Tripathi, Renu , Srivastava, Anubhooti , Ramachandran, Ravishankar , Tripathi, R P . Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents. : Central Drug Research Institute (CDRI), India; 2557.