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M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease
นักวิจัย : Sarkar, Supriya , Gupta, Vikas , Kumar, Ajay , Chaudhary, Manoj , Diyundi, Subhash , Sehajpal, P K , Thangaraj, Kumarasamy , Singh, Rajender
คำค้น : End stage renal disease , REN gene , AGT gene , Renin angiotensin system
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : Nephron, 2015, 129(2), 104-108 , http://hdl.handle.net/123456789/1438
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8880
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Background/Aims This study aimed at investigating if M235T polymorphism in the AGT gene and A/GI8-83 polymorphism in the REN gene correlate with the end stage renal disease (ESRD). Methods We analyzed one hundred and seventy three patients having ESRD and three hundred and twenty-nine individuals with normal kidney function for differences in the genotype distribution of AGT-M235T and REN-A/GI8-83 polymorphisms between the two groups. The data for cases and controls were compared using chi square test. Results We found significantly higher levels of serum creatinine and CRP in cases in comparison to controls (P< 0.0001). Data comparison showed significant association of AGT M235T substitution with ESRD in dominant model (p = 0.008) and in comparison of heterozygous substitution against homozygous common genotype (p = 0.005). Similarly, REN A/GI8-83 polymorphism showed a significant difference in the distribution of genotypes between cases and controls (p= < 0.038) such that heterozygous substitution was significantly more common in the ESRD cases in comparison to homozygous common genotype (p = 0.023). Conclusion We conclude that heterozygous substitutions at AGT M235T and REN A/GI8-83 loci correlate significantly with ESRD in a north Indian population.

บรรณานุกรม :
Sarkar, Supriya , Gupta, Vikas , Kumar, Ajay , Chaudhary, Manoj , Diyundi, Subhash , Sehajpal, P K , Thangaraj, Kumarasamy , Singh, Rajender . (2558). M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease.
    : Central Drug Research Institute (CDRI), India.
Sarkar, Supriya , Gupta, Vikas , Kumar, Ajay , Chaudhary, Manoj , Diyundi, Subhash , Sehajpal, P K , Thangaraj, Kumarasamy , Singh, Rajender . 2558. "M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease".
    : Central Drug Research Institute (CDRI), India.
Sarkar, Supriya , Gupta, Vikas , Kumar, Ajay , Chaudhary, Manoj , Diyundi, Subhash , Sehajpal, P K , Thangaraj, Kumarasamy , Singh, Rajender . "M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease."
    : Central Drug Research Institute (CDRI), India, 2558. Print.
Sarkar, Supriya , Gupta, Vikas , Kumar, Ajay , Chaudhary, Manoj , Diyundi, Subhash , Sehajpal, P K , Thangaraj, Kumarasamy , Singh, Rajender . M235T Polymorphism in the AGT Gene and A/GI8-83 Substitution in the REN Gene Correlate with End Stage Renal Disease. : Central Drug Research Institute (CDRI), India; 2558.