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New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents
นักวิจัย : Chauhan, Kuldeep , Sharma, Moni , Trivedi, Priyanka , Chaturvedi, Vinita , Chauhan, P. M. S.
คำค้น : Rhodanine , Tetrazole , Mycobacterium tuberculosis , Cytotoxicity
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Bioorganic & Medicinal Chemistry Letters, 2014, 24 (17), 4166–4170 , http://hdl.handle.net/123456789/1419
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8738
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In search of potential therapeutics for tuberculosis, we describe here the synthesis and in vitro antitubercular activity of a novel series of thiazolone piperazine tetrazole derivatives. Among all the synthesized derivatives, four compounds (10, 14, 20 and 33) exhibited more potent activity (MIC = 3.08, 3.01, 2.62 and 2.51 μM) than ethambutol (MIC = 9.78 μM) and pyrazinamide (MIC = 101.53 μM) against Mycobacterium tuberculosis. Furthermore, they displayed no toxicity against Vero cells (C1008) and mouse bone marrow derived macrophages (MBMDMɸ). These investigated analogues have emerged as possible lead molecule to enlarge the scope of the study.

บรรณานุกรม :
Chauhan, Kuldeep , Sharma, Moni , Trivedi, Priyanka , Chaturvedi, Vinita , Chauhan, P. M. S. . (2557). New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents.
    : Central Drug Research Institute (CDRI), India.
Chauhan, Kuldeep , Sharma, Moni , Trivedi, Priyanka , Chaturvedi, Vinita , Chauhan, P. M. S. . 2557. "New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents".
    : Central Drug Research Institute (CDRI), India.
Chauhan, Kuldeep , Sharma, Moni , Trivedi, Priyanka , Chaturvedi, Vinita , Chauhan, P. M. S. . "New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Chauhan, Kuldeep , Sharma, Moni , Trivedi, Priyanka , Chaturvedi, Vinita , Chauhan, P. M. S. . New class of methyl tetrazole based hybrid of (Z)-5-benzylidene-2-(piperazin-1-yl) thiazol-4(%H)-one as potent antitubercular agents. : Central Drug Research Institute (CDRI), India; 2557.