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Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents
นักวิจัย : Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K
คำค้น : 2,3,6-Trideoxy Sugars , 1,2,3-Triazole , Molecular Hybridization , Click Chemistry , Antimicrobial Agents , Penicillin binding protein
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : European Journal of Medicinal Chemistry, 2014, 83, 474-89 , http://hdl.handle.net/123456789/1413
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8723
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Here, we describe a molecular hybridization inspired design and synthesis of novel 6-triazolyl 2,3,6-trideoxy sugars as promising new broad-spectrum antimicrobial agents using click chemistry in key step. These compounds showed MIC between 0.39-50µg/mL against different native and resistant bacteria and fungi with no toxicity. Among them, compound 29 was the most active molecule with MIC 0.78µg/mL against Staphylococcus aureus and Klebsiella pneumoniae and 3.12µg/mL against methicillin- and vancomycin-resistant S. aureus. Compound 26 was the most potent anti-fungal candidate with MIC 0.39µg/mL against T. mentagrophytes. Compound 46 was found to be promising with broad-spectrum activity against both bacterial and fungal strains. The bioinformatic studies involving bacteria’s protein co-crystals prompted penicillin binding protein-2 as the most likely target of these compounds.

บรรณานุกรม :
Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . (2557). Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents.
    : Central Drug Research Institute (CDRI), India.
Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . 2557. "Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents".
    : Central Drug Research Institute (CDRI), India.
Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . "Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents."
    : Central Drug Research Institute (CDRI), India, 2557. Print.
Sharma, Smriti , Saquib, Mohammad , Verma, Saroj , Mishra, N N , Shukla, P K , Srivastava, Ranjana , Prabhakar, Y S , Shaw, A K . Synthesis of 2,3,6-trideoxy sugar triazole hybrids as potential new broad spectrum antimicrobial agents. : Central Drug Research Institute (CDRI), India; 2557.