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Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems

หน่วยงาน Central Drug Research Institute (CDRI), India

รายละเอียด

ชื่อเรื่อง : Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems
นักวิจัย : Wahajuddin , Taneja, Isha , Arora, Sumit , Raju, K S R , Siddiqui, Nida
คำค้น : Conjugates , Disposition , Efflux transporters , Enteric recirculation , Isoflavones , Phase II metabolism
หน่วยงาน : Central Drug Research Institute (CDRI), India
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Current Drug Metabolism, 2013, 14(4), 369-380 , http://hdl.handle.net/123456789/1380
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : CSIR-CDRI Communication No. 8436
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Dietary isoflavones, popularly known as phytoestrogens, represent one of the most biologically active classes of flavonoids. Numerous in vitroandin vivostudies provide convincing evidence regarding their beneficial effects on human health. These isoflavones are increasingly being investigated as potential alternate therapies for a range of hormone-dependent conditions, including cancer, menopausal symptoms, osteoporosis and cardiovascular diseases. However, they exhibit poor oral bioavailability which limits their clinical utility in humans. The reason being, they are substrates of a plethora of enzymes and transporters and undergo extensive conjugative metabolismwhich facilitate their rapid elimination from biological systems. In addition, a number of experimental studies have also revealed that these isoflavones are potent inhibitors of various cytochrome P450 isoforms and transporters which play an important role in the disposition of many commonly prescribed drugs. Thus, there arise chances of observing clinically relevant herb-drug interactions which could sometimes be life-threatening. This review gives a comprehensive understanding of these dietary phytoestrogens with regard to their absorption, biodistribution and the role of enzyme-transporter interplay affecting their disposition in biological systems. Further, the effects of these phytoestrogens on the activity and kinetics of drug metabolizing enzymes and various clinically relevant influx/efflux transporters and the resulting diet-drug interactions have also been discussed.

บรรณานุกรม :
Wahajuddin , Taneja, Isha , Arora, Sumit , Raju, K S R , Siddiqui, Nida . (2556). Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems.
    : Central Drug Research Institute (CDRI), India.
Wahajuddin , Taneja, Isha , Arora, Sumit , Raju, K S R , Siddiqui, Nida . 2556. "Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems".
    : Central Drug Research Institute (CDRI), India.
Wahajuddin , Taneja, Isha , Arora, Sumit , Raju, K S R , Siddiqui, Nida . "Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems."
    : Central Drug Research Institute (CDRI), India, 2556. Print.
Wahajuddin , Taneja, Isha , Arora, Sumit , Raju, K S R , Siddiqui, Nida . Disposition of Pharmacologically Active Dietary Isoflavones in Biological Systems. : Central Drug Research Institute (CDRI), India; 2556.