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Piglets cloned from induced pluripotent stem cells

หน่วยงาน Central Queensland University, Australia

รายละเอียด

ชื่อเรื่อง : Piglets cloned from induced pluripotent stem cells
นักวิจัย : Fan, Nana. , Chen, Jijun. , Han, Jianyong. , Zhou, Qi. , Pan, Dengke. , Yang, Dongshan. , Zhao, Bentian. , Ouyang, Zhen. , Liu, Zhaoming. , Zhao, Yu. , Lin, Lin. , Zhong, Chongming. , Wang, Quanlei. , Wang, Shouqi. , Xu, Ying. , Luan, Jing. , Liang, Yu. , Yang, Zhenzhen. , Li, Jing. , Lu, Chunxia. , Vajta, Gabor. , Li, Ziyi. , Ouyang, Hongsheng. , Wang, Huayan. , Wang, Yong. , Yang, Yang. , Liu, Zhonghua. , Wei, Hong. , Luan, Zhidong. , Esteban, Miguel A. , Deng, Hongkui. , Yang, Huanming. , Pei, Duanqing. , Li, Ning. , Pei, Gang. , Liu, Lin. , Du, Yutao. , Xiao, Lei. , Lai, Liangxue. , Shang, Zhouchun. , Dou, Hongwei. , Ji, Guanghzhen. , Zou, Qingjian. , Wu, Lu. , He, Lixiazi. , Wang, Fang. , Liu, Na. , Liu, Kai.
คำค้น : LIBRARY OF CONGRESS NEEDED , Experimental development. , 830308 Pigs , 070206 Animal Reproduction. , Piglets -- Cloned -- Pluripotent stem cells , Journal Article. Refereed, Scholarly Journal
หน่วยงาน : Central Queensland University, Australia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : http://hdl.cqu.edu.au/10018/930420
ที่มา : Fan, N, Chen, J, Shang, Z, Dou, H, Ji, G, Zou, Q, Wu, L, He, L, Wang, F, Liu, K, Liu, N, Han, J, Zhou, Q, Pan, D, Yang, D, Zhao, B, Ouyang, Z, Liu, Z, Zhao, Y, Lin, L, Zhong, C, Wang, Q, Wang, S, Xu, Y, Luan, J, Liang, Y, Yang, Z, Li, J, Lu, C, Vajta, G, Li, Z, Ouyang, H, Wang, H, Wang, Y, Yang, Y, Liu, Z, Wei, H, Luan, Z, Esteban, MA, Deng, H, Yang, H, Pei, D, Li, N, Pei, G, Liu, L, Du, Y, Xiao, L & Lai, L 2012, 'Piglets cloned from induced pluripotent stem cells', Cell Research, vol. 23, no. 1, pp. 157-161, http://dx.doi.org/10.1038/cr.2012.176
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell research. Shanghai China : Nature Publishing Group, 2012. Vol. 23, no. 1 (January 2013), p. 162-166 5 pages Refereed 1001-0602 1748-7838 (online) , ACQUIRE [electronic resource] : Central Queensland University Institutional Repository.
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Embryonic stem (ES) cells are powerful tools for generating genetically modified animals that can assist in advancing our knowledge of mammalian physiology and disease. Pigs provide outstanding models of human genetic diseases due to the striking similarities to human anatomy, physiology and genetics, but progress with porcine genetic engineering has been hampered by the lack of germline-competent pig ES cells. To overcome this limitation, genetically modified pigs have been produced using genetically modified somatic cells and nuclear transfer (NT). Yet, somatic cells exhibit limited proliferative capacity and have an extremely low frequency of homologous recombination compared to ES cells. Hence, only a few knockout pig models have been reported thus far using standard gene-targeting approaches.

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