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PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides

หน่วยงาน Central Queensland University, Australia

รายละเอียด

ชื่อเรื่อง : PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides
นักวิจัย : Chen, Wenhan. , Guo, Wanwu. , Ma, Zhiqiang. , Huang, Yan Xin.
คำค้น : LIBRARY OF CONGRESS NEEDED , Applied research. , 890201 Application Software Packages (excl. Computer Games) , 890205 Information Processing Services (incl. Data Entry and Capture) , 890206 Internet Hosting Services (incl. Application Hosting Services) , 080105 Expert Systems. , 080301 Bioinformatics Software. , 060102 Bioinformatics. , Epitope mapping -- Peptides -- Online tool -- PepMapper , Journal Article. Refereed, Scholarly Journal
หน่วยงาน : Central Queensland University, Australia
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : http://hdl.cqu.edu.au/10018/927893 , http://dx.doi.org/10.1371/journal.pone.0037869
ที่มา : Chen, W, Guo, W, Ma, Z & Huang, Y 2012, 'PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides', PLoS ONE, vol. 7, no. 5, e37869, pp. 1-10. http://dx.doi.org/10.1371/journal.pone.0037869
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS one. United States : Public Library of Science, 2012. Vol. 7, no. 5 (May 2012), p. 1-10 10 pages Refereed 1932-6203 (online) , ACQUIRE [electronic resource] : Central Queensland University Institutional Repository.
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Epitope mapping from affinity-selected peptides has become popular in epitope prediction, and correspondingly many Web-based tools have been developed in recent years. However, the performance of these tools varies in different circumstances. To address this problem, we employed an ensemble approach to incorporate two popular Web tools, MimoPro and Pep-3D-Search, together for taking advantages offered by both methods so as to give users more choices, support and convenience for their specific purposes of epitope-peptide mapping. The combined operation of Union finds as many associated peptides as possible from both methods, which increases sensitivity in finding potential epitopic regions on a given antigen surface. The combined operation of Intersection achieves to some extent the mutual verification by the two methods and hence increases the likelihood of locating the genuine epitopic region on a given antigen in relation to the interacting peptides. The Consistency between Intersection and Union is an indirect sufficient condition to assess the likelihood of successful peptide-epitope mapping. On average from 27 tests, the combined operations of PepMapper outperformed either MimoPro or Pep-3D-Search alone. Therefore, PepMapper is another multipurpose mapping tool for epitope prediction from affinity-selected peptides. The Web server can be freely accessed at: http://informatics.nenu.edu.cn/PepMapper/

บรรณานุกรม :
Chen, Wenhan. , Guo, Wanwu. , Ma, Zhiqiang. , Huang, Yan Xin. . (2555). PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides.
    กรุงเทพมหานคร : Central Queensland University, Australia.
Chen, Wenhan. , Guo, Wanwu. , Ma, Zhiqiang. , Huang, Yan Xin. . 2555. "PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides".
    กรุงเทพมหานคร : Central Queensland University, Australia.
Chen, Wenhan. , Guo, Wanwu. , Ma, Zhiqiang. , Huang, Yan Xin. . "PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides."
    กรุงเทพมหานคร : Central Queensland University, Australia, 2555. Print.
Chen, Wenhan. , Guo, Wanwu. , Ma, Zhiqiang. , Huang, Yan Xin. . PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides. กรุงเทพมหานคร : Central Queensland University, Australia; 2555.