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POPX2 phosphatase regulates the KIF3 kinesin motor complex

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : POPX2 phosphatase regulates the KIF3 kinesin motor complex
นักวิจัย : Phang, Hui-Qun , Hoon, Jing-Ling , Lai, Soak-Kuan , Zeng, Yukai , Chiam, Keng-Hwee , Li, Hoi-Yeung , Koh, Cheng-Gee
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Phang, H.-Q., Hoon, J.-L., Lai, S.-K., Zeng, Y., Chiam, K.-H., Li, H.-Y., et al. (2014). POPX2 phosphatase regulates the KIF3 kinesin motor complex. Journal of cell science, 127(4), 727-739. , http://hdl.handle.net/10220/25111 , http://dx.doi.org/10.1242/jcs.126482
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of cell science
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The kinesin motors are important in the regulation of cellular functions such as protein trafficking, spindle organization and centrosome separation. In this study, we have identified POPX2, a serine-threonine phosphatase, as an interacting partner of the KAP3 subunit of the kinesin-2 motor. The kinesin-2 motor is a heterotrimeric complex composed of KIF3A, KIF3B motor subunits and KAP3, the non-motor subunit, which binds the cargo. Here we report that the phosphatase POPX2 is a negative regulator of the trafficking of N-cadherin and other cargoes; consequently, it markedly influences cell-cell adhesion. POPX2 affects trafficking by determining the phosphorylation status of KIF3A at serine 690. This is consistent with the observation that the KIF3A-S690A mutant is defective in cargo trafficking. Our studies also implicate CaMKII as the kinase that phosphorylates KIF3A at serine 690. These results strongly suggest that POPX2 and CaMKII are a phosphatase-kinase pair that regulates kinesin-mediated transport and cell-cell adhesion.

บรรณานุกรม :
Phang, Hui-Qun , Hoon, Jing-Ling , Lai, Soak-Kuan , Zeng, Yukai , Chiam, Keng-Hwee , Li, Hoi-Yeung , Koh, Cheng-Gee . (2557). POPX2 phosphatase regulates the KIF3 kinesin motor complex.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Phang, Hui-Qun , Hoon, Jing-Ling , Lai, Soak-Kuan , Zeng, Yukai , Chiam, Keng-Hwee , Li, Hoi-Yeung , Koh, Cheng-Gee . 2557. "POPX2 phosphatase regulates the KIF3 kinesin motor complex".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Phang, Hui-Qun , Hoon, Jing-Ling , Lai, Soak-Kuan , Zeng, Yukai , Chiam, Keng-Hwee , Li, Hoi-Yeung , Koh, Cheng-Gee . "POPX2 phosphatase regulates the KIF3 kinesin motor complex."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Phang, Hui-Qun , Hoon, Jing-Ling , Lai, Soak-Kuan , Zeng, Yukai , Chiam, Keng-Hwee , Li, Hoi-Yeung , Koh, Cheng-Gee . POPX2 phosphatase regulates the KIF3 kinesin motor complex. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.