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Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells
นักวิจัย : Guo, Jinhong , Chen, Liang , Ai, Ye , Cheng, Yuanbing , Li, Chang Ming , Kang, Yuejun , Wang, Zhiming
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Guo, J., Chen, L., Ai, Y., Cheng, Y., Li, C. M., Kang, Y., et al. (2014). Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells. ELECTROPHORESIS, in press. , 0173-0835 , http://hdl.handle.net/10220/25102 , http://dx.doi.org/10.1002/elps.201400376
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : ELECTROPHORESIS
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Portable diagnostic devices have emerged as important tools in various biomedical applications since they can provide an effective solution for low-cost and rapid clinical diagnosis. In this paper, we present a micropore-based resistive cytometer for the detection and enumeration of biological cells. The proposed device was fabricated on a silicon wafer by a standard microelectromechanical system processing technology, which enables a mass production of the proposed chip. The working principle of this cytometer is based upon a bias potential modulated pulse, originating from the biological particle's physical blockage of the micropore. Polystyrene particles of different sizes (7, 10, and 16 μm) were used to test and calibrate the proposed device. A finite element simulation was developed to predict the bias potential modulated pulse (peak amplitude vs. pulse bandwidth), which can provide critical insight into the design of this microfluidic flow cytometer. Furthermore, HeLa cells (a type of tumor cell lines) spiked in a suspension of blood cells, including red blood cells and white blood cells, were used to assess the performance for detecting and counting tumor cells. The proposed microfluidic flow cytometer is able to provide a promising platform to address the current unmet need for point-of-care clinical diagnosis.

บรรณานุกรม :
Guo, Jinhong , Chen, Liang , Ai, Ye , Cheng, Yuanbing , Li, Chang Ming , Kang, Yuejun , Wang, Zhiming . (2557). Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Guo, Jinhong , Chen, Liang , Ai, Ye , Cheng, Yuanbing , Li, Chang Ming , Kang, Yuejun , Wang, Zhiming . 2557. "Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Guo, Jinhong , Chen, Liang , Ai, Ye , Cheng, Yuanbing , Li, Chang Ming , Kang, Yuejun , Wang, Zhiming . "Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Guo, Jinhong , Chen, Liang , Ai, Ye , Cheng, Yuanbing , Li, Chang Ming , Kang, Yuejun , Wang, Zhiming . Numerical and experimental characterization of solid-state micropore-based cytometer for detection and enumeration of biological cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.