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Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression

หน่วยงาน จุฬาลงกรณ์มหาวิทยาลัย

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ชื่อเรื่อง : Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression
นักวิจัย : Pimpayao Sodsai
คำค้น : Systemic lupus erythematosus , Notch genes
หน่วยงาน : จุฬาลงกรณ์มหาวิทยาลัย
ผู้ร่วมงาน : Nattiya Hirankarn , Tanapat Palaga , Chulalongkorn University. Graduate School
ปีพิมพ์ : 2549
อ้างอิง : http://cuir.car.chula.ac.th/handle/123456789/14677
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Thesis (M.Sc.)--Chulalongkorn University, 2006

Systemic lupus erthematosus (SLE) is a prototype to autoimmune disease characterized by tissue deposition of autoantibody immune complex formation. However, etiology of disease remains unclaified. Defects of T lymphocytes lead to loss of immunological tolerance and support autoantibody production suggested that they may consistently have a central role in pathogenesis of SLE. Notch signaling is an evolutionarily conserved pathway responsible thymocyte development, activation, proliferation, differentiation and T cell functions. Several evidences suggest Notch signaling involvement in autoimmune disorders. The aim of this study was to investigate the correlation of Notch1 receptor expression in T lymphocytes with disease progression. Twenty-two Thai SLE patients and eleven healthy controls were recruited for the study. Notch1 expression in PHA-stimulated T lymphocytes of SLE patients that indicated significantly defective regulation of Notch1 in activated T lymphocytes of SLE patients with active stage (p=0.025) while stimulated T lymphocytes of SLE patients with inactive stage were indifferent expression of Notch 1 compared with healthy controls that quantified by real-time RT-PCR. It was confirmed by conventional RT-PCR that showed deceleration of Notch1 expression in SLE (p = 0.015). As well as Notch1 protein expression, it was downregulated in active SLE compared to controls and inactive SLE (p=0.001 and 0.037, respectively). However, Hes 1 that was target of Notch signaling did not reduce expression in SLE T lymphocytes. Moreover, proliferation capacity in SLE patients did not defect. These results showed converse correlation of Notch 1 expression with severity of SLE. The data reveal the defective Notch1 in T cells that is possibly uncovered new factor of pathogenesis in SLE.

บรรณานุกรม :
Pimpayao Sodsai . (2549). Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression.
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Pimpayao Sodsai . 2549. "Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression".
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย.
Pimpayao Sodsai . "Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression."
    กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย, 2549. Print.
Pimpayao Sodsai . Correlation of Notch1 receptor expression in T lymphocytes from SLE patients with disease progression. กรุงเทพมหานคร : จุฬาลงกรณ์มหาวิทยาลัย; 2549.