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A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug
นักวิจัย : Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli
คำค้น : DRNTU::Engineering::Materials::Nanostructured materials
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2558
อ้างอิง : Zhao, Y., Luo, Z., Li, M., Qu, Q., Ma, X., Yu, S.-H., et al. (2015). A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug. Angewandte chemie International edition, 54(3), 919-922. , 1433-7851 , http://hdl.handle.net/10220/25002 , http://dx.doi.org/10.1002/anie.201408510
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Angewandte chemie International edition
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Biomedical applications of nontoxic amorphous calcium carbonate (ACC) nanoparticles have mainly been restricted because of their aqueous instability. To improve their stability in physiological environments while retaining their pH-responsiveness, a novel nanoreactor of ACC–doxorubicin (DOX)@silica was developed for drug delivery for use in cancer therapy. As a result of its rationally engineered structure, this nanoreactor maintains a low drug leakage in physiological and lysosomal/endosomal environments, and responds specifically to pH 6.5 to release the drug. This unique ACC–DOX@silica nanoreactor releases DOX precisely in the weakly acidic microenvironment of cancer cells and results in efficient cell death, thus showing its great potential as a desirable chemotherapeutic nanosystem for cancer therapy.

บรรณานุกรม :
Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . (2558). A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . 2558. "A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . "A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2558. Print.
Zhao, Yang , Luo, Zhong , Li, Menghuan , Qu, Qiuyu , Ma, Xing , Yu, Shu-Hong , Zhao, Yanli . A preloaded amorphous calcium carbonate/doxorubicin@silica nanoreactor for pH-responsive delivery of an anticancer drug. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2558.