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Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation
นักวิจัย : Tham, Muly , Tan, Kar Wai , Keeble, Jo , Wang, Xiaojie , Hubert, Sandra , Barron, Luke , Tan, Nguan Soon , Kato, Masashi , Prevost-Blondel, Armelle , Angeli, Veronique , Abastado, Jean-Pierre
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Tham, M., Tan, K. W., Keeble, Jo., Wang, X., Hubert, S., Barron, L., et al. (2014). Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation. Oncotarget, 5(23), 12027-12042. , 1949-2553 , http://hdl.handle.net/10220/24702 , http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=2482
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Oncotarget
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

M2 macrophages promote tumor growth and metastasis, but their interactions with specific tumor cell populations are poorly characterized. Using a mouse model of spontaneous melanoma, we showed that CD34- but not CD34+ tumor-initiating cells (TICs) depend on M2 macrophages for survival and proliferation. Tumor-associated macrophages (TAMs) and macrophage-conditioned media protected CD34- TICs from chemotherapy in vitro. In vivo, while inhibition of CD115 suppressed the macrophage-dependent CD34- TIC population, chemotherapy accelerated its development. The ability of TICs to respond to TAMs was acquired during melanoma progression and immediately preceded a surge in metastatic outgrowth. TAM-derived transforming growth factor-β (TGFβ) and polyamines produced via the Arginase pathway were critical for stimulation of TICs and synergized to promote their growth.

บรรณานุกรม :
Tham, Muly , Tan, Kar Wai , Keeble, Jo , Wang, Xiaojie , Hubert, Sandra , Barron, Luke , Tan, Nguan Soon , Kato, Masashi , Prevost-Blondel, Armelle , Angeli, Veronique , Abastado, Jean-Pierre . (2557). Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tham, Muly , Tan, Kar Wai , Keeble, Jo , Wang, Xiaojie , Hubert, Sandra , Barron, Luke , Tan, Nguan Soon , Kato, Masashi , Prevost-Blondel, Armelle , Angeli, Veronique , Abastado, Jean-Pierre . 2557. "Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tham, Muly , Tan, Kar Wai , Keeble, Jo , Wang, Xiaojie , Hubert, Sandra , Barron, Luke , Tan, Nguan Soon , Kato, Masashi , Prevost-Blondel, Armelle , Angeli, Veronique , Abastado, Jean-Pierre . "Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Tham, Muly , Tan, Kar Wai , Keeble, Jo , Wang, Xiaojie , Hubert, Sandra , Barron, Luke , Tan, Nguan Soon , Kato, Masashi , Prevost-Blondel, Armelle , Angeli, Veronique , Abastado, Jean-Pierre . Melanoma-initiating cells exploit M2 macrophage TGFβ and arginase pathway for survival and proliferation. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.