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Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides
นักวิจัย : Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E.
คำค้น : DRNTU::Science::Chemistry::Organic chemistry::Oxidation
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Petersen, R., Le Quement, S. T., & Nielsen, T. E. (2014). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. Angewandte chemie international edition, 53(44), 11778-11782. , 1433-7851 , http://hdl.handle.net/10220/24634 , http://dx.doi.org/10.1002/anie.201405747
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Angewandte chemie international edition
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Massive efforts in molecular library synthesis have strived for the development of synthesis methodology which systematically delivers natural product-like compounds of high spatial complexity. Herein, we present a conceptually simple approach that builds on the power of solid-phase peptide synthesis to assemble precursor peptides (oligomers) designed to undergo oxidative cascade reactions. By harnessing the structural side-chain diversity and inherent stereochemical features offered by readily available amino acids (monomers), a proof-of-concept collection of 54 skeletally and stereochemically diverse compounds was generated, and selected compounds were elaborated into isoform-selective metalloprotease inhibitors.

บรรณานุกรม :
Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . (2557). Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . 2557. "Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . "Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Petersen, Rico , Le Quement, Sebastian T. , Nielsen, Thomas E. . Synthesis of a natural product-like compound collection through oxidative cleavage and cyclization of linear peptides. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.