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Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection
นักวิจัย : Cerny, Daniela , Haniffa, Muzlifah , Shin, Amanda , Bigliardi, Paul , Tan, Bien Keem , Lee, Bernett , Poidinger, Michael , Tan, Ern Yu , Ginhoux, Florent , Fink, Katja
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Bacteria
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : Kuhn, Richard J.
ปีพิมพ์ : 2557
อ้างอิง : Cerny, D., Haniffa, M., Shin, A., Bigliardi, P., Tan, B. K., Lee, B., et al. (2014). Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection. PLoS pathogens, 10(12), e1004548-. , 1553-7374 , http://hdl.handle.net/10220/24602 , http://dx.doi.org/10.1371/journal.ppat.1004548
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS pathogens
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Dengue is a growing global concern with 390 million people infected each year. Dengue virus (DENV) is transmitted by mosquitoes, thus host cells in the skin are the first point of contact with the virus. Human skin contains several populations of antigen-presenting cells which could drive the immune response to DENV in vivo: epidermal Langerhans cells (LCs), three populations of dermal dendritic cells (DCs), and macrophages. Using samples of normal human skin we detected productive infection of CD14+ and CD1c+ DCs, LCs and dermal macrophages, which was independent of DC-SIGN expression. LCs produced the highest viral titers and were less sensitive to IFN-β. Nanostring gene expression data showed significant up-regulation of IFN-β, STAT-1 and CCL5 upon viral exposure in susceptible DC populations. In mice infected intra-dermally with DENV we detected parallel populations of infected DCs originating from the dermis and migrating to the skin-draining lymph nodes. Therefore dermal DCs may simultaneously facilitate systemic spread of DENV and initiate the adaptive anti-viral immune response.

บรรณานุกรม :
Cerny, Daniela , Haniffa, Muzlifah , Shin, Amanda , Bigliardi, Paul , Tan, Bien Keem , Lee, Bernett , Poidinger, Michael , Tan, Ern Yu , Ginhoux, Florent , Fink, Katja . (2557). Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Cerny, Daniela , Haniffa, Muzlifah , Shin, Amanda , Bigliardi, Paul , Tan, Bien Keem , Lee, Bernett , Poidinger, Michael , Tan, Ern Yu , Ginhoux, Florent , Fink, Katja . 2557. "Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Cerny, Daniela , Haniffa, Muzlifah , Shin, Amanda , Bigliardi, Paul , Tan, Bien Keem , Lee, Bernett , Poidinger, Michael , Tan, Ern Yu , Ginhoux, Florent , Fink, Katja . "Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Cerny, Daniela , Haniffa, Muzlifah , Shin, Amanda , Bigliardi, Paul , Tan, Bien Keem , Lee, Bernett , Poidinger, Michael , Tan, Ern Yu , Ginhoux, Florent , Fink, Katja . Selective susceptibility of human skin antigen presenting cells to productive dengue virus infection. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.