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Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles
นักวิจัย : Lee, Wei Li , Guo, Wei Mei , Ho, Vincent H. B. , Saha, Amitaksha , Chong, Han Chung , Tan, Nguan Soon , Widjaja, Effendi , Tan, Ern Yu , Loo, Say Chye Joachim
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Lee, W. L., Guo, W. M., Ho, V. H. B., Saha, A., Chong, H. C., Tan, N. S., et al. (2014). Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles. Small, 10(19), 3986-3996. , 1613-6810 , http://hdl.handle.net/10220/24526 , http://dx.doi.org/10.1002/smll.201400536
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Small
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

First-line cancer chemotherapy necessitates high parenteral dosage and repeated dosing of a combination of drugs over a prolonged period. Current commercially available chemotherapeutic agents, such as Doxil and Taxol, are only capable of delivering single drug in a bolus dose. The aim of this study is to develop dual-drug-loaded, multilayered microparticles and to investigate their antitumor efficacy compared with single-drug-loaded particles. Results show hydrophilic doxorubicin HCl (DOX) and hydrophobic paclitaxel (PTX) localized in the poly(dl-lactic-co-glycolic acid, 50:50) (PLGA) shell and in the poly(l-lactic acid) (PLLA) core, respectively. The introduction of poly[(1,6-bis-carboxyphenoxy) hexane] (PCPH) into PLGA/PLLA microparticles causes PTX to be localized in the PLLA and PCPH mid-layers, whereas DOX is found in both the PLGA shell and core. PLGA/PLLA/PCPH microparticles with denser shells allow better control of DOX release. A delayed release of PTX is observed with the addition of PCPH. Three-dimensional MCF-7 spheroid studies demonstrate that controlled co-delivery of DOX and PTX from multilayered microparticles produces a greater reduction in spheroid growth rate compared with single-drug-loaded particles. This study provides mechanistic insights into how distinctive structure of multilayered microparticles can be designed to modulate the release profiles of anticancer drugs, and how co-delivery can potentially provide better antitumor response.

ASTAR (Agency for Sci., Tech. and Research, S’pore)

บรรณานุกรม :
Lee, Wei Li , Guo, Wei Mei , Ho, Vincent H. B. , Saha, Amitaksha , Chong, Han Chung , Tan, Nguan Soon , Widjaja, Effendi , Tan, Ern Yu , Loo, Say Chye Joachim . (2557). Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Guo, Wei Mei , Ho, Vincent H. B. , Saha, Amitaksha , Chong, Han Chung , Tan, Nguan Soon , Widjaja, Effendi , Tan, Ern Yu , Loo, Say Chye Joachim . 2557. "Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Guo, Wei Mei , Ho, Vincent H. B. , Saha, Amitaksha , Chong, Han Chung , Tan, Nguan Soon , Widjaja, Effendi , Tan, Ern Yu , Loo, Say Chye Joachim . "Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Lee, Wei Li , Guo, Wei Mei , Ho, Vincent H. B. , Saha, Amitaksha , Chong, Han Chung , Tan, Nguan Soon , Widjaja, Effendi , Tan, Ern Yu , Loo, Say Chye Joachim . Inhibition of 3-D tumor spheroids by timed-released hydrophilic and hydrophobic drugs from multilayered polymeric microparticles. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.