ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Apelin attenuates oxidative stress in human adipocytes

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Apelin attenuates oxidative stress in human adipocytes
นักวิจัย : Than, Aung , Zhang, Xiaohong , Leow, Melvin Khee-Shing , Poh, Chueh Loo , Chong, Seow Khoon , Chen, Peng
คำค้น : DRNTU::Engineering::Bioengineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Than, A., Zhang, X., Leow, M. K.-S., Poh, C. L., Chong, S. K., & Chen, P. (2014). Apelin attenuates oxidative stress in human adipocytes. Journal of biological chemistry, 289(6), 3763-3774. , http://hdl.handle.net/10220/24131 , http://dx.doi.org/10.1074/jbc.M113.526210
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of biological chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

It has been recently recognized that the increased oxidative stress (ROS overproduction) in obese condition is a key contributor to the pathogenesis of obesity-associated metabolic diseases. Apelin is an adipocytokine secreted by adipocytes, and known for its anti-obesity and anti-diabetic properties. In obesity, both oxidative stress and plasma level of apelin are increased. However, the regulatory roles of apelin on oxidative stress in adipocytes remain unknown. In the present study, we provide evidence that apelin, through its interaction with apelin receptor (APJ), suppresses production and release of reactive oxygen species (ROS) in adipocytes. This is further supported by the observations that apelin promotes the expression of anti-oxidant enzymes via MAPK kinase/ERK and AMPK pathways, and suppresses the expression of pro-oxidant enzyme via AMPK pathway. We further demonstrate that apelin is able to relieve oxidative stress -induced dysregulations of the expression of anti- and pro- oxidant enzymes, mitochondrial biogenesis and function, as well as release of pro- and anti- inflammatory adipocytokines. This study, for the first time, reveals the antioxidant properties of apelin in adipocytes, and suggests its potential as a novel therapeutic target for metabolic diseases.

บรรณานุกรม :
Than, Aung , Zhang, Xiaohong , Leow, Melvin Khee-Shing , Poh, Chueh Loo , Chong, Seow Khoon , Chen, Peng . (2557). Apelin attenuates oxidative stress in human adipocytes.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Zhang, Xiaohong , Leow, Melvin Khee-Shing , Poh, Chueh Loo , Chong, Seow Khoon , Chen, Peng . 2557. "Apelin attenuates oxidative stress in human adipocytes".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Than, Aung , Zhang, Xiaohong , Leow, Melvin Khee-Shing , Poh, Chueh Loo , Chong, Seow Khoon , Chen, Peng . "Apelin attenuates oxidative stress in human adipocytes."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Than, Aung , Zhang, Xiaohong , Leow, Melvin Khee-Shing , Poh, Chueh Loo , Chong, Seow Khoon , Chen, Peng . Apelin attenuates oxidative stress in human adipocytes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.