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The potential for a controlled human infection platform in Singapore

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The potential for a controlled human infection platform in Singapore
นักวิจัย : Balasingam, Shobana , Horby, Peter , Wilder-Smith, Annelies
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Balasingam, S., Horby, P., & Wilder-Smith, A. (2014). The potential for a controlled human infection platform in Singapore. Singapore medical journal, 55(9), 456-461. , 0037-5675 , http://hdl.handle.net/10220/24086 , http://dx.doi.org/10.11622/smedj.2014114
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Singapore medical journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

For over 100 years, controlled human infection (CHI) studies have been performed to advance the understanding of the pathogenesis, treatment and prevention of infectious diseases. This methodology has seen a resurgence, as it offers an efficient model for selecting the most promising agents for further development from available candidates. CHI studies are utilised to bridge safety and immunogenicity testing and phase II/III efficacy studies. However, as this platform is not currently utilised in Asia, opportunities to study therapeutics and vaccines for infections that are important in Asia are missed. This review examines the regulatory differences for CHI studies between countries and summarises other regulatory differences in clinical trials as a whole. We found that the regulations that would apply to CHI studies in Singapore closely mirror those in the United Kingdom, and conclude that the regulatory and ethical guidelines in Singapore are compatible with the conduct of CHI studies.

บรรณานุกรม :
Balasingam, Shobana , Horby, Peter , Wilder-Smith, Annelies . (2557). The potential for a controlled human infection platform in Singapore.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Balasingam, Shobana , Horby, Peter , Wilder-Smith, Annelies . 2557. "The potential for a controlled human infection platform in Singapore".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Balasingam, Shobana , Horby, Peter , Wilder-Smith, Annelies . "The potential for a controlled human infection platform in Singapore."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Balasingam, Shobana , Horby, Peter , Wilder-Smith, Annelies . The potential for a controlled human infection platform in Singapore. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.