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Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia
นักวิจัย : Yin, Lu , Zheng, Dahai , Limmon, Gino V , Leung, Nicola HN , Xu, Shuoyu , Rajapakse, Jagath C , Hanry, Yu , Chow, Vincent T. K. , Chen, Jianzhu
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Immunology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Yin, L., Zheng, D., Limmon, G., Leung, N. HN., Xu, S., Rajapakse, J. C., et al. (2014). Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respiratory research, 15(1). , 1465-9921 , http://hdl.handle.net/10220/24081 , http://dx.doi.org/10.1186/s12931-014-0116-z
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Respiratory research
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Background: Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to influenza virus infection, however, how aging affects the lung tissue damage and repair has not been completely elucidated. Methods: Aged (16–18 months old) and young (2–3 months old) mice were infected with influenza virus intratracheally. Body weight and mortality were monitored. Different days after infection, lung sections were stained to estimate the overall lung tissue damage and for club cells, pro-SPC+ bronchiolar epithelial cells, alveolar type I and II cells to quantify their frequencies using automated image analysis algorithms. Results: Following influenza infection, aged mice lose more weight and die from otherwise sub-lethal influenza infection in young mice. Although there is no difference in damage and regeneration of club cells between the young and the aged mice, damage to alveolar type I and II cells (AT1s and AT2s) is exacerbated, and regeneration of AT2s and their precursors (pro-SPC-positive bronchiolar epithelial cells) is significantly delayed in the aged mice. We further show that oseltamivir treatment reduces virus load and lung damage, and promotes pulmonary recovery from infection in the aged mice. Conclusions: These findings show that aging increases susceptibility of the distal lung epithelium to influenza infection and delays the emergence of pro-SPC positive progenitor cells during the repair process. Our findings also shed light on possible approaches to enhance the clinical management of severe influenza pneumonia in the elderly.

บรรณานุกรม :
Yin, Lu , Zheng, Dahai , Limmon, Gino V , Leung, Nicola HN , Xu, Shuoyu , Rajapakse, Jagath C , Hanry, Yu , Chow, Vincent T. K. , Chen, Jianzhu . (2557). Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yin, Lu , Zheng, Dahai , Limmon, Gino V , Leung, Nicola HN , Xu, Shuoyu , Rajapakse, Jagath C , Hanry, Yu , Chow, Vincent T. K. , Chen, Jianzhu . 2557. "Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yin, Lu , Zheng, Dahai , Limmon, Gino V , Leung, Nicola HN , Xu, Shuoyu , Rajapakse, Jagath C , Hanry, Yu , Chow, Vincent T. K. , Chen, Jianzhu . "Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Yin, Lu , Zheng, Dahai , Limmon, Gino V , Leung, Nicola HN , Xu, Shuoyu , Rajapakse, Jagath C , Hanry, Yu , Chow, Vincent T. K. , Chen, Jianzhu . Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.