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Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities
นักวิจัย : Manavalan, Arulmani , Ramachandran, Umamaheswari , Sundaramurthi, Husvinee , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Feng, Zhi Wei , Heese, Klaus
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Manavalan, A., Ramachandran, U., Sundaramurthi, H., Mishra, M., Sze, S. K., Hu, J.-M., et al. (2012). Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. International journal of biochemistry and molecular biology, 3(2), 219-241. , 2152-4114 , http://hdl.handle.net/10220/23952 , http://www.ijbmb.org/1205001A.html
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : International journal of biochemistry and molecular biology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Tianma (Gastrodia elata Blume) is a traditional Chinese medicine (TCM) often used for the treatment of headache, convulsions, hypertension and neurodegenerative diseases. Tianma also modulates the cleavage of the amyloid precursor protein App and cognitive functions in mice. The neuronal actions of tianma thus led us to investigate its specific effects on neuronal signalling. Accordingly, this pilot study was designed to examine the effects of tianma on the proteome metabolism in differentiated mouse neuronal N2a cells using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach. We identified 2178 proteins, out of which 74 were found to be altered upon tianma treatment in differentiated mouse neuronal N2a cells. Based on the observed data obtained, we hypothesize that tianma could promote neuro-regenerative processes by inhibiting stress-related proteins and mobilizing neuroprotective genes such as Nxn, Dbnl, Mobkl3, Clic4, Mki67 and Bax with various regenerative modalities and capacities related to neuro-synaptic plasticity.

บรรณานุกรม :
Manavalan, Arulmani , Ramachandran, Umamaheswari , Sundaramurthi, Husvinee , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Feng, Zhi Wei , Heese, Klaus . (2555). Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Manavalan, Arulmani , Ramachandran, Umamaheswari , Sundaramurthi, Husvinee , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Feng, Zhi Wei , Heese, Klaus . 2555. "Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Manavalan, Arulmani , Ramachandran, Umamaheswari , Sundaramurthi, Husvinee , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Feng, Zhi Wei , Heese, Klaus . "Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Manavalan, Arulmani , Ramachandran, Umamaheswari , Sundaramurthi, Husvinee , Mishra, Manisha , Sze, Siu Kwan , Hu, Jiang-Miao , Feng, Zhi Wei , Heese, Klaus . Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.