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Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application.
นักวิจัย : Liu, Yun Xiao.
คำค้น : DRNTU::Science::Medicine::Tissue engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : Liu, Y. X. (2010). Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application. Doctoral thesis, Nanyang Technological University, Singapore. , http://hdl.handle.net/10356/40817
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Hydrogels are crosslinked polymer networks with high water content. They have the capability to mimic native ECM and thus are highly desirable as 3D scaffolds for cell encapsulation. Synthetic hydrogels for cell encapsulation have hitherto been based on poly(ethylene glycol), which is non-natural, non-biodegradable, and only terminal-functionalizable. Dextran is highly hydrophilic but also biodegradable and pendant-functionalizable. More importantly, it resembles the native glycosaminoglycans. This study aims to fabricate hydrogels based on natural dextran and gelatin, which could promote 3D SMC spreading and proliferation. Two series of hydrogels were fabricated. The first hydrogel series is based on the interpenetrating polymer network (IPN) of gelatin and dextran bifunctionalized with methacrylate (MA) and aldehyde (AD) (Dex-MA-AD). These IPN hydrogels not only supported endothelial cell (EC) adhesion and spreading on the surface, but also allowed encapsulated SMCs to proliferate and spread in the bulk interior of the hydrogel; however, the Schiff base reaction was not easily controllable and while SMC spreading within the hydrogel did occur, it was rather limited.

บรรณานุกรม :
Liu, Yun Xiao. . (2553). Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yun Xiao. . 2553. "Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Liu, Yun Xiao. . "Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2553. Print.
Liu, Yun Xiao. . Biomimetic hydrogels based on natural dextran and gelatin for vascular tissue engineering application.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2553.