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Studies on the host-virus interactions of coronaviruses.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Studies on the host-virus interactions of coronaviruses.
นักวิจัย : Zhong, Yanxin.
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Virology.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Zhong, Y. X. (2012). Studies on the host-virus interactions of coronaviruses. Doctoral thesis, Nanyang Technological University, Singapore. , http://hdl.handle.net/10356/49502
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : -
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Virus-induced apoptosis and host antiviral innate immunity are key issues in understanding virus-host interactions and viral pathogenesis. Coronavirus infection of mammalian cells induces apoptotic and host innate immune responses. Global gene expression profiles are determined in coronavirus-infected Vero cells by Affymetrix array, using avian coronavirus infectious bronchitis virus (IBV) as a model system, to reveal up-regulation of both pro-apoptotic B cell lymphoma-2 (BCL-2)-antagonist/killer 1 (Bak) and pro-survival myeloid cell leukemia-1 (Mcl-1). Apoptosis occurred earlier in IBV-infected cells silenced with short interfering RNA targeting Mcl-1 (siMcl-1), and was delayed in siBak cells. Up-regulation of RNA helicases from the RIG-I-like receptor (RLR) family, Melanoma differentiation-associated gene 5 (MDA5) and Retinoic-inducible gene I (RIG-I), was also observed in IBV-infected cells, leading to downstream Mitochondrial antiviral signalling (MAVS) adaptor protein activation for interferon induction in response to viral invasion. RIG-I, MDA5 and MAVS also play a part in modulating IBV-induced apoptosis. Bcl-2 family proteins, too, regulates MAVS cleavage during apoptosis, thus further establishing a link between MAVS and intrinsic apoptotic pathway activation in the mitochondria during host innate immunity induction.

บรรณานุกรม :
Zhong, Yanxin. . (2555). Studies on the host-virus interactions of coronaviruses..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhong, Yanxin. . 2555. "Studies on the host-virus interactions of coronaviruses.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhong, Yanxin. . "Studies on the host-virus interactions of coronaviruses.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Zhong, Yanxin. . Studies on the host-virus interactions of coronaviruses.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.