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“Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy.
นักวิจัย : Zhang, Yan , Das, Gautom Kumar , Vijayaragavan, Vimalan , Xu, Qing Chi , Padmanabhan, Parasuraman , Bhakoo, Kishore K. , Tamil Selvan, Subramanian , Tan, Timothy Thatt Yang
คำค้น : DRNTU::Science::Physics
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Zhang, Y., Das, G. K., Vijayaragavan, V., Xu, Q. C., Padmanabhan, P., Bhakoo, K. K., et al. (2014). “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy. Nanoscale, 6(21), 12609-12617. , http://hdl.handle.net/10220/20951 , http://dx.doi.org/10.1039/C4NR01717J
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Nanoscale
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The current work reports a type of “smart” lanthanide-based theranostic nanoprobe, NaDyF4:Yb3+/NaGdF4:Yb3+,Er3+, which is able to circumvent the up-converting poisoning effect of Dy3+ ions to give efficient near infrared (980 nm) triggered up-conversion fluorescence, and offers not only excellent dark T2-weighted MR contrast but also tunable bright and T1-weighted MR contrast properties. Due to the efficient up-converted energy transfer from the nanocrystals to chlorin e6 (Ce6) photosensitizers loaded onto the nanocrystals, cytotoxic singlet oxygen was generated and photodynamic therapy was demonstrated. Therefore, the current multifunctional nanocrystals could be potentially useful in various image-guided diagnoses where bright or dark MRI contrast could be selectively tuned to optimize image quality, but also as an efficient and more penetrative near-infrared activated photodynamic therapy agent.

บรรณานุกรม :
Zhang, Yan , Das, Gautom Kumar , Vijayaragavan, Vimalan , Xu, Qing Chi , Padmanabhan, Parasuraman , Bhakoo, Kishore K. , Tamil Selvan, Subramanian , Tan, Timothy Thatt Yang . (2557). “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Yan , Das, Gautom Kumar , Vijayaragavan, Vimalan , Xu, Qing Chi , Padmanabhan, Parasuraman , Bhakoo, Kishore K. , Tamil Selvan, Subramanian , Tan, Timothy Thatt Yang . 2557. "“Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Yan , Das, Gautom Kumar , Vijayaragavan, Vimalan , Xu, Qing Chi , Padmanabhan, Parasuraman , Bhakoo, Kishore K. , Tamil Selvan, Subramanian , Tan, Timothy Thatt Yang . "“Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Zhang, Yan , Das, Gautom Kumar , Vijayaragavan, Vimalan , Xu, Qing Chi , Padmanabhan, Parasuraman , Bhakoo, Kishore K. , Tamil Selvan, Subramanian , Tan, Timothy Thatt Yang . “Smart” theranostic lanthanide nanoprobes with simultaneous up-conversion fluorescence and tunable T1–T2 magnetic resonance imaging contrast and near-infrared activated photodynamic therapy.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.