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Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins
นักวิจัย : Tjin, Monica Suryana , Chua, Alvin Wen Choong , Ma, Dong Rui , Lee, Seng Teik , Fong, Eileen
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Tjin, M. S., Chua, A. W. C., Ma, D. R., Lee, S. T., & Fong, E. (2014). Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins. Macromolecular bioscience, 14(8), 1125-1134. , 1616-5187 , http://hdl.handle.net/10220/20681 , http://dx.doi.org/10.1002/mabi.201400015
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Macromolecular bioscience
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Cell-matrix interactions play critical roles in regulating cellular behavior in wound repair and regeneration of the human skin. In particular, human skin keratinocytes express several key integrins such as alpha5beta1, alpha3beta1, and alpha2beta1 for binding to the extracellular matrix (ECM) present in the basement membrane in uninjured skin. To mimic these key integrin-ECM interactions, artificial ECM (aECM) proteins containing functional domains derived from laminin 5, type IV collagen, fibronectin, and elastin are prepared. Human skin keratinocyte cell responses on the aECM proteins are specific to the cell-binding domain present in each construct. Keratinocyte attachment to the aECM protein substrates is also mediated by specific integrin-material interactions. In addition, the aECM proteins are able to support the proliferation of keratinocyte stem cells, demonstrating their promise for use in skin tissue engineering.

บรรณานุกรม :
Tjin, Monica Suryana , Chua, Alvin Wen Choong , Ma, Dong Rui , Lee, Seng Teik , Fong, Eileen . (2557). Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tjin, Monica Suryana , Chua, Alvin Wen Choong , Ma, Dong Rui , Lee, Seng Teik , Fong, Eileen . 2557. "Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tjin, Monica Suryana , Chua, Alvin Wen Choong , Ma, Dong Rui , Lee, Seng Teik , Fong, Eileen . "Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Tjin, Monica Suryana , Chua, Alvin Wen Choong , Ma, Dong Rui , Lee, Seng Teik , Fong, Eileen . Human epidermal keratinocyte cell response on integrin-specific artificial extracellular matrix proteins. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.