ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines
นักวิจัย : Yap, Jeanette See Leng , Ding, Yi , Yang, Xiang-Yuan , Wong, Jonathan , Li, Yongxin , Pullarkat, Sumod A. , Leung, Pak-Hing
คำค้น : DRNTU::Science::Chemistry::Inorganic chemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Yap, J. S. L., Ding, Y., Yang, X. Y., Wong, J., Li, Y., Pullarkat, S. A., & Leung, P. H. (2014). Mechanistic Insights into the Pd II -Catalyzed Chemoselective N -Demethylation vs. Cyclometalation Reactivity Pathways in 1-Aryl- N , N -dimethylethanamines . European Journal of Inorganic Chemistry, 2014(29), 5046-5052. , 1434-1948 , http://hdl.handle.net/10220/20485 , http://dx.doi.org/10.1002/ejic.201402547
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : European journal of inorganic chemistry
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Two structurally isomeric substituted N,N-dimethylethanamines have been prepared. Treatment of the 2,4-di-tert-butylphenyl isomer with PdII ions generated the ortho-metalated complexes. On the other hand, treatment of the 2,5-di-tert-butylphenyl-substituted amine resulted in the unexpected chemoselective cleavage of one of the three N–C bonds, thus generating the corresponding secondary amine. The N-demethylation process could be catalyzed at room temperature by palladium(II) catalysts such as PdCl2 or Pd(OAc)2. Furthermore, treatment with a stoichiometric amount of PdII ions gave a metal complex in which both secondary amines were bound to Pd in an N-monodentate fashion. When triethylamine was introduced, one of the N-ethyl groups in NEt3 was cleaved, and an unexpected heteroamine complex was produced. The products generated were isolated and characterized by X-ray crystallography. Mechanistic insights into the cyclometalation and C–N cleavage observed are discussed.

บรรณานุกรม :
Yap, Jeanette See Leng , Ding, Yi , Yang, Xiang-Yuan , Wong, Jonathan , Li, Yongxin , Pullarkat, Sumod A. , Leung, Pak-Hing . (2557). Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yap, Jeanette See Leng , Ding, Yi , Yang, Xiang-Yuan , Wong, Jonathan , Li, Yongxin , Pullarkat, Sumod A. , Leung, Pak-Hing . 2557. "Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yap, Jeanette See Leng , Ding, Yi , Yang, Xiang-Yuan , Wong, Jonathan , Li, Yongxin , Pullarkat, Sumod A. , Leung, Pak-Hing . "Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Yap, Jeanette See Leng , Ding, Yi , Yang, Xiang-Yuan , Wong, Jonathan , Li, Yongxin , Pullarkat, Sumod A. , Leung, Pak-Hing . Mechanistic insights into the PdII-catalyzed chemoselective N-demethylation vs. cyclometalation reactivity pathways in 1-Aryl-N,N-dimethylethanamines. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.