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Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities
นักวิจัย : Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei
คำค้น : DRNTU::Science::Chemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Ding, F., Leow, M. L., Ma, J., William, R., Liao, H., & Liu, X. W. (2014). Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities. Chemistry - an Asian journal, 9(9), 2548-2554. , 1861-4728 , http://hdl.handle.net/10220/20684 , http://dx.doi.org/10.1002/asia.201402466
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemistry - an Asian journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A collective synthesis of 4-hydroxy-2-pyridone alkaloids—specifically, pretenellin B, prebassianin B, farinosone A, militarione D, pyridovericin, and torrubiellone C—has been achieved. Key steps include using a strategic convergent method to synthesize the densely substituted pyridone key intermediate by Suzuki–Miyaura cross-coupling reaction, a divergent synthesis approach of target molecules by aldol condensation of pyridone intermediate with homologous aldehydes, and an iterative synthesis of homologous aldehydes with all-trans-polyene backbones. Interestingly, among the six tumor cell lines investigated, torrubiellone C was found to induce potent and apoptotic inhibitory activities on Jurkat T cells with IC50 values of 7.05 μm. Hence, this approach could potentially contribute to the synthesis of bioactive small-molecule libraries as well as drug discovery.

บรรณานุกรม :
Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . (2557). Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . 2557. "Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . "Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Ding, Feiqing , Leow, Min Li , Ma, Jimei , William, Ronny , Liao, Hongze , Liu, Xue-Wei . Collective synthesis of 4-Hydroxy-2-pyridone alkaloids and their antiproliferation activities. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.