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Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity
นักวิจัย : Purnama, Christina , Ng, See Liang , Tetlak, Piotr , Setiagani, Yolanda Aphrilia , Kandasamy, Matheswaran , Baalasubramanian, Sivasankar , Karjalainen, Klaus , Ruedl, Christiane
คำค้น : DRNTU::Science::Biological sciences::Microbiology::Immunology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Purnama, C., Ng, S. L., Tetlak, P., Setiagani, Y. A., Kandasamy, M., Baalasubramanian, S., et al. (2014). Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity. European journal of immunology, 44(7), 2003-2012. , 0014-2980 , http://hdl.handle.net/10220/20697 , http://dx.doi.org/10.1002/eji.201344359
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : European journal of immunology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Alveolar macrophages (AMs), localized at the pulmonary air-tissue interface, are one of the first lines of defense that interact with inhaled airborne pathogens such as influenza viruses. By using a new CD169-DTR transgenic mouse strain we demonstrate that specific and highly controlled in vivo ablation of this myeloid cell subset leads to severe impairment of the innate, but not adaptive, immune responses and critically affects the progression of the disease. In fact, AM-ablated mice, infected with a normally sublethal dose of PR8 influenza virus, showed dramatically increased virus load in the lungs, severe airway inflammation, pulmonary edema and vascular leakage, which caused the death of the infected animals. Our data highlight the possibilities for new therapeutic strategies focusing on modulation of AMs, which may efficiently boost innate responses to influenza infections.

บรรณานุกรม :
Purnama, Christina , Ng, See Liang , Tetlak, Piotr , Setiagani, Yolanda Aphrilia , Kandasamy, Matheswaran , Baalasubramanian, Sivasankar , Karjalainen, Klaus , Ruedl, Christiane . (2557). Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Purnama, Christina , Ng, See Liang , Tetlak, Piotr , Setiagani, Yolanda Aphrilia , Kandasamy, Matheswaran , Baalasubramanian, Sivasankar , Karjalainen, Klaus , Ruedl, Christiane . 2557. "Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Purnama, Christina , Ng, See Liang , Tetlak, Piotr , Setiagani, Yolanda Aphrilia , Kandasamy, Matheswaran , Baalasubramanian, Sivasankar , Karjalainen, Klaus , Ruedl, Christiane . "Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Purnama, Christina , Ng, See Liang , Tetlak, Piotr , Setiagani, Yolanda Aphrilia , Kandasamy, Matheswaran , Baalasubramanian, Sivasankar , Karjalainen, Klaus , Ruedl, Christiane . Transient ablation of alveolar macrophages leads to massive pathology of influenza infection without affecting cellular adaptive immunity. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.