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Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups
นักวิจัย : Tan, Si Yu , Ang, Chung Yen , Li, Peizhou , Yap, Qi Ming , Zhao, Yanli
คำค้น : DRNTU::Science::Chemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Tan, S. Y., Ang, C. Y., Li, P., Yap, Q. M., & Zhao, Y. (2014). Drug Encapsulation and Release by Mesoporous Silica Nanoparticles: The Effect of Surface Functional Groups. Chemistry - A European Journal, 20(36), 11276-11282. , 0947-6539 , http://hdl.handle.net/10220/20483 , http://dx.doi.org/10.1002/chem.201403551
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemistry - a European journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Mesoporous silica nanoparticles (MSNPs) have been widely used as drug carriers for stimuli-responsive drug delivery. Herein, a catalysis screening technique was adopted for analyzing the effects of chain length, terminal group, and density of disulfide-appended functional ligands on the surface of MSNPs on drug-loading capacity and glutathione-triggered drug-release kinetics. The ligand with an intermediate length (5 carbon atoms) and a bulky terminal group (cyclohexyl) that complexes with theβ-cyclodextrin ring showed the highest drug loading capacity as well as good release kinetics. In addition, decreasing the surface coverage of the functional ligands led to an enhancement in drug release. In vitro drug-delivery experiments on a melanoma cell line (B16-F10) by using the functionalized MSNPs further supported the conclusion. The results obtained may serve as a general guide for developing more effective MSNP systems for drug delivery.

บรรณานุกรม :
Tan, Si Yu , Ang, Chung Yen , Li, Peizhou , Yap, Qi Ming , Zhao, Yanli . (2557). Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Si Yu , Ang, Chung Yen , Li, Peizhou , Yap, Qi Ming , Zhao, Yanli . 2557. "Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Si Yu , Ang, Chung Yen , Li, Peizhou , Yap, Qi Ming , Zhao, Yanli . "Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Tan, Si Yu , Ang, Chung Yen , Li, Peizhou , Yap, Qi Ming , Zhao, Yanli . Drug encapsulation and release by mesoporous silica nanoparticles : the effect of surface functional groups. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.