ridm@nrct.go.th   ระบบคลังข้อมูลงานวิจัยไทย   รายการโปรดที่คุณเลือกไว้

Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis
นักวิจัย : Teo, Jeanette , Tan, Sean Yang-Yi , Liu, Yang , Tay, Martin , Ding, Yichen , Li, Yingying , Kjelleberg, Staffan , Givskov, Michael , Lin, Raymond T. P. , Yang, Liang
คำค้น : DRNTU::Science::Biological sciences::Microbiology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Teo, J., Tan, S. Y.-Y., Liu, Y., Tay, M., Ding, Y., Li, Y., et al. (2014). Comparative Genomic Analysis of Malaria Mosquito Vector-Associated Novel Pathogen Elizabethkingia anophelis. Genome Biology and Evolution, 6(5), 1158-1165. , 1759-6653 , http://hdl.handle.net/10220/20267 , http://dx.doi.org/10.1093/gbe/evu094
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Genome biology and evolution
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Acquisition of Elizabethkingia infections in intensive care units (ICUs) has risen in the past decade. Treatment of Elizabethkingia infections is challenging due to the lack of effective therapeutic regimens, leading to a high mortality rate. Elizabethkingia infections have long been attributed to Elizabethkingia meningoseptica. Recently, we used whole-genome sequencing to reveal that E. anophelis is the pathogenic agent for an Elizabethkingia outbreak at two ICUs. We performed comparative genomic analysis of seven hospital-isolated E. anophelis strains with five available Elizabethkingia spp. genomes deposited in the National Center for Biotechnology Information Database. A pan-genomic approach was applied to identify the core- and pan-genome for the Elizabethkingia genus. We showed that unlike the hospital-isolated pathogen E. meningoseptica ATCC 12535 strain, the hospital-isolated E. anophelis strains have genome content and organization similar to the E. anophelis Ag1 and R26 strains isolated from the midgut microbiota of the malaria mosquito vector Anopheles gambiae. Both the core- and accessory genomes of Elizabethkingia spp. possess genes conferring antibiotic resistance and virulence. Our study highlights that E. anophelis is an emerging bacterial pathogen for hospital environments.

บรรณานุกรม :
Teo, Jeanette , Tan, Sean Yang-Yi , Liu, Yang , Tay, Martin , Ding, Yichen , Li, Yingying , Kjelleberg, Staffan , Givskov, Michael , Lin, Raymond T. P. , Yang, Liang . (2557). Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Teo, Jeanette , Tan, Sean Yang-Yi , Liu, Yang , Tay, Martin , Ding, Yichen , Li, Yingying , Kjelleberg, Staffan , Givskov, Michael , Lin, Raymond T. P. , Yang, Liang . 2557. "Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Teo, Jeanette , Tan, Sean Yang-Yi , Liu, Yang , Tay, Martin , Ding, Yichen , Li, Yingying , Kjelleberg, Staffan , Givskov, Michael , Lin, Raymond T. P. , Yang, Liang . "Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Teo, Jeanette , Tan, Sean Yang-Yi , Liu, Yang , Tay, Martin , Ding, Yichen , Li, Yingying , Kjelleberg, Staffan , Givskov, Michael , Lin, Raymond T. P. , Yang, Liang . Comparative genomic analysis of malaria mosquito vector-associated novel pathogen Elizabethkingia anophelis. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.