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Formation and degradation of biodegradable triple-layered microparticles

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Formation and degradation of biodegradable triple-layered microparticles
นักวิจัย : Lee, Wei Li , Hong, Meiju , Widjaja, Effendi , Loo, Say Chye Joachim
คำค้น : DRNTU::Engineering::Materials
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2553
อ้างอิง : Lee, W. L., Hong, M., Widjaja, E., & Loo, S. C. J. (2010). Formation and Degradation of Biodegradable Triple-Layered Microparticles. Macromolecular Rapid Communications, 31(13), 1193-1200. , 1022-1336 , http://hdl.handle.net/10220/20231 , http://dx.doi.org/10.1002/marc.200900811
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Macromolecular rapid communications
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

In this work, we report how biodegradable triple-layered microparticles can be fabricated through a simple, reliable, and economical one-step solvent evaporation technique. Characterization of triple-layered PLGA (shell)/PLLA (middle layer)/EVA (core) microparticles was conducted and their formation mechanism was described. Subsequently, in vitro hydrolytic degradation of these microparticles was investigated. It was found that the PLGA shell degraded rapidly leaving behind double-walled microparticles of PLLA/EVA after 40 days. The middle PLLA layer degraded more rapidly than expected because of the migration of PLGA oligomers that created a hydrophilic and acidic microenvironment in the PLLA layer. These degradation results therefore provide important insights into how triple-layered microparticles degrade, and how their degradation characteristics affect the drug releasing properties of these novel microparticles.

บรรณานุกรม :
Lee, Wei Li , Hong, Meiju , Widjaja, Effendi , Loo, Say Chye Joachim . (2553). Formation and degradation of biodegradable triple-layered microparticles.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Hong, Meiju , Widjaja, Effendi , Loo, Say Chye Joachim . 2553. "Formation and degradation of biodegradable triple-layered microparticles".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wei Li , Hong, Meiju , Widjaja, Effendi , Loo, Say Chye Joachim . "Formation and degradation of biodegradable triple-layered microparticles."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2553. Print.
Lee, Wei Li , Hong, Meiju , Widjaja, Effendi , Loo, Say Chye Joachim . Formation and degradation of biodegradable triple-layered microparticles. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2553.