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Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study
นักวิจัย : Lei, Qiong , Lee, Wilson Liangwei , Li, Tianhu
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Lei, Q., Lee, W. L., & Li, T. (2013). Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study. European Journal of Lipid Science and Technology, 115(2), 232-238. , 1438-7697 , http://hdl.handle.net/10220/19828 , http://dx.doi.org/10.1002/ejlt.201200174
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : European journal of lipid science and technology
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The increasing number of health issues caused by obesity and lack of healthy and efficient fat substitutes require development on new fat substitute. This study proposes a new potential reduced-calorie structured triacylglycerol (TAG) of “1,3-medium-chain, 2-short-chain triglycerides (MSM)” configuration, and the fat substitution method is based on the suppression of 2-monoacylglycerol absorption into intestinal cells, which would decrease the recombination of TAG and reduce lipid absorption in the digestive tract. A molecular probe, 1,3-dicapryloyl-2-acetylglycerol, is offered for nutritionists to conduct further study on its metabolism in human body. The synthesis method for this structured TAG starts from the lipase-catalyzed esterification between glycerol and caprylic acid, yielding 1,3-dicapryloylglycerol, and is followed by direct esterification with acetic anhydride to form 1,3-dicapryloyl-2-acetylglycerol. Its structure is characterized by FTIR,1H NMR,13C NMR, and LC-ESI-MS.

บรรณานุกรม :
Lei, Qiong , Lee, Wilson Liangwei , Li, Tianhu . (2555). Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lei, Qiong , Lee, Wilson Liangwei , Li, Tianhu . 2555. "Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lei, Qiong , Lee, Wilson Liangwei , Li, Tianhu . "Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Lei, Qiong , Lee, Wilson Liangwei , Li, Tianhu . Design and synthesis of 1,3-dicapryloyl-2-acetylglycerol as molecular probe for triacylglycerol metabolism study. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.