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Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies
นักวิจัย : Li, Xue-juan , Mishra, Shital K. , Wu, Min , Zhang, Fan , Zheng, Jie
คำค้น : DRNTU::Science::Medicine::Biomedical engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Li, X.-j., Mishra, S. K., Wu, M., Zhang, F., & Zheng, J. (2014). Syn-Lethality: An Integrative Knowledge Base of Synthetic Lethality towards Discovery of Selective Anticancer Therapies. BioMed Research International, 2014, 196034-. , 2314-6133 , http://hdl.handle.net/10220/19741 , http://dx.doi.org/10.1155/2014/196034
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : BioMed research international
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells. While numerous SL interactions have been identified in yeast, only a few have been known in human. There is a pressing need to systematically discover and understand SL interactions specific to human cancer. In this paper, we present Syn-Lethality, the first integrative knowledge base of SL that is dedicated to human cancer. It integrates experimentally discovered and verified human SL gene pairs into a network, associated with annotations of gene function, pathway, and molecular mechanisms. It also includes yeast SL genes from high-throughput screenings which are mapped to orthologous human genes. Such an integrative knowledge base, organized as a relational database with user interface for searching and network visualization, will greatly expedite the discovery of novel anticancer drug targets based on synthetic lethality interactions. The database can be downloaded as a stand-alone Java application.

บรรณานุกรม :
Li, Xue-juan , Mishra, Shital K. , Wu, Min , Zhang, Fan , Zheng, Jie . (2557). Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Li, Xue-juan , Mishra, Shital K. , Wu, Min , Zhang, Fan , Zheng, Jie . 2557. "Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Li, Xue-juan , Mishra, Shital K. , Wu, Min , Zhang, Fan , Zheng, Jie . "Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Li, Xue-juan , Mishra, Shital K. , Wu, Min , Zhang, Fan , Zheng, Jie . Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.