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Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols
นักวิจัย : Chen, Wenchao , Jing, Zhengzhong , Chin, Kek Foo , Qiao, Baokun , Zhao, Yan , Yan, Lin , Tan, Choon-Hong , Jiang, Zhiyong
คำค้น : DRNTU::Science::Chemistry::Organic chemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Chen, W., Jing, Z., Chin, K. F., Qiao, B., Zhao, Y., Yan, L., et al. (2014). Catalytic Asymmetric Conjugate Addition of Mercaptans to β-Substituted-β-Trifluoromethyl Oxazolidinone Enoates: Access to Chiral Trifluoromethylated Tertiary Thioethers and Thiols. Advanced Synthesis & Catalysis, 356(6), 1292-1300. , 1615-4150 , http://hdl.handle.net/10220/19696 , http://dx.doi.org/10.1002/adsc.201301027
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Advanced synthesis & catalysis
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

The first asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates has been developed. The opposite enantiomers of adducts, containing a trifluoromethylated hetero-quaternary stereogenic centers, could be obtained by utilizing two pseudo-enantiomeric Cinchona alkaloid-derived tertiary amine/squaramides as catalysts. Potassium dihydrogen phosphate was found to accelerate the reaction rate without compromising the enantioselective excess. A variety of chiral trifluoromethylated tertiary thioethers and thiols were readily prepared with excellent enantioselectivity.

บรรณานุกรม :
Chen, Wenchao , Jing, Zhengzhong , Chin, Kek Foo , Qiao, Baokun , Zhao, Yan , Yan, Lin , Tan, Choon-Hong , Jiang, Zhiyong . (2557). Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Wenchao , Jing, Zhengzhong , Chin, Kek Foo , Qiao, Baokun , Zhao, Yan , Yan, Lin , Tan, Choon-Hong , Jiang, Zhiyong . 2557. "Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Wenchao , Jing, Zhengzhong , Chin, Kek Foo , Qiao, Baokun , Zhao, Yan , Yan, Lin , Tan, Choon-Hong , Jiang, Zhiyong . "Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Chen, Wenchao , Jing, Zhengzhong , Chin, Kek Foo , Qiao, Baokun , Zhao, Yan , Yan, Lin , Tan, Choon-Hong , Jiang, Zhiyong . Catalytic asymmetric conjugate addition of mercaptans to β-substituted-β-trifluoromethyl oxazolidinone enoates: access to chiral trifluoromethylated tertiary thioethers and thiols. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.