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Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging
นักวิจัย : Zhang, Huacheng , Ma, Xing , Nguyen, Kim Truc , Zeng, Yongfei , Tai, Shuhui , Zhao, Yanli
คำค้น : DRNTU::Engineering::Materials::Biomaterials
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Zhang, H., Ma, X., Nguyen, K. T., Zeng, Y., Tai, S., & Zhao, Y. (2014). Water-Soluble Pillararene-Functionalized Graphene Oxide for In Vitro Raman and Fluorescence Dual-Mode Imaging. ChemPlusChem, 79(3), 462-469. , 2192-6506 , http://hdl.handle.net/10220/19691 , http://dx.doi.org/10.1002/cplu.201300408
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : ChemPlusChem
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

This study provides a successful preparation of biocompatible hybrid materials (1-GO and 2-GO) by the integration of graphene oxide (GO) with water-soluble pillararenes (bolaamphiphile 1 and tadpolelike amphiphile 2) for dual-mode Raman and fluorescence bioimaging in vitro. The investigations show that pillararenes 1 and 2 were loaded onto the surface of GO through strong hydrogen-bonding interactions. Aqueous suspensions of 1-GO and 2-GO are stable and can be kept for a long time. After confirming their good biocompatibility by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, the 1-GO and 2-GO hybrids were endocytosed by HeLa cells for in vitro Raman imaging. It was found that 1-GO presents better Raman imaging than 2-GO. When a fluorescent guest molecule, bipyridinium derivative 3, was added into the suspensions of the hybrids, the suspensions of 1-GO and 2-GO were as stable as the original. The suspensions of the inclusion complexes (1-GO[DOT OPERATOR]3 and 2-GO[DOT OPERATOR]3) formed from 1-GO and 2-GO with 3 can also be endocytosed by HeLa cells to enable in vitro fluorescence imaging to be performed. It was found that 1-GO[DOT OPERATOR]3 performs better than 2-GO[DOT OPERATOR]3. The current research has determined the capacities of pillararene-modified GO for combined bioimaging, which paves the way for using these biocompatible materials towards dual-mode diagnostics.

บรรณานุกรม :
Zhang, Huacheng , Ma, Xing , Nguyen, Kim Truc , Zeng, Yongfei , Tai, Shuhui , Zhao, Yanli . (2557). Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Huacheng , Ma, Xing , Nguyen, Kim Truc , Zeng, Yongfei , Tai, Shuhui , Zhao, Yanli . 2557. "Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zhang, Huacheng , Ma, Xing , Nguyen, Kim Truc , Zeng, Yongfei , Tai, Shuhui , Zhao, Yanli . "Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Zhang, Huacheng , Ma, Xing , Nguyen, Kim Truc , Zeng, Yongfei , Tai, Shuhui , Zhao, Yanli . Water-Soluble pillararene-functionalized graphene oxide for in vitro raman and fluorescence dual-mode imaging. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.