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Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study
นักวิจัย : Lee, Shirley Hui Zhi , Leong, Weng Kee , Top, Siden , Vessières, Anne
คำค้น : DRNTU::Science::Biological sciences::Biochemistry
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Lee, H. Z. S., Leong, W. K., Top, S., & Vessières, A. (2014). Cytotoxic Triosmium Carbonyl Clusters: A Structure-Activity Relationship Study. ChemMedChem, 9(7), 1453–1457. , 1860-7179 , http://hdl.handle.net/10220/19690 , http://dx.doi.org/10.1002/cmdc.201300394
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : ChemMedChem
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A structure–activity relationship (SAR) study of the triosmium carbonyl cluster Os3(CO)10(NCCH3)2 was carried out with a series of clusters of the general formula Os3(CO)12−nLn, cationic osmium clusters and a hemi-labile maltolato-Os cluster. The SAR results showed that good solubility in DMSO and at least one vacant site are required for cytotoxicity. In vitro evaluation of these new compounds showed that some are selectively active against estrogen receptor (ER)-independent MDA-MB-231 breast cancer cell lines relative to ER-dependent MCF-7 breast cancer cells, suggesting that the compounds have a different biological target specific to MDA-MB-231 cells. In particular, the maltolato cluster exhibits strong antiproliferative activity, with an IC50 value of 3 μM after only 24 h incubation. Additionally, biochemical assays conducted with the cationic cluster show that it induces apoptosis, although a biological target has not yet been identified. Further research to establish the molecular targets of these compounds and to develop improved organometallic clusters as potential breast cancer therapeutics is underway.

บรรณานุกรม :
Lee, Shirley Hui Zhi , Leong, Weng Kee , Top, Siden , Vessières, Anne . (2556). Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Shirley Hui Zhi , Leong, Weng Kee , Top, Siden , Vessières, Anne . 2556. "Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Shirley Hui Zhi , Leong, Weng Kee , Top, Siden , Vessières, Anne . "Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Lee, Shirley Hui Zhi , Leong, Weng Kee , Top, Siden , Vessières, Anne . Cytotoxic triosmium carbonyl clusters : a structure-activity relationship study. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.