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Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses
นักวิจัย : Kim, Jinsook , Lee, Soojung , Tsuda, Sachiko , Zhang, Xuying , Asrican, Brent , Gloss, Bernd , Feng, Guoping , Augustine, George J.
คำค้น : DRNTU::Science::Medicine
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Kim, J., Lee, S., Tsuda, S., Zhang, X., Asrican, B., Gloss, B., et al. (2014). Optogenetic Mapping of Cerebellar Inhibitory Circuitry Reveals Spatially Biased Coordination of Interneurons via Electrical Synapses. Cell Reports, 7, 1-13. , 2211-1247 , http://hdl.handle.net/10220/19679 , http://dx.doi.org/10.1016/j.celrep.2014.04.047
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

We used high-speed optogenetic mapping technology to examine the spatial organization of local inhibitory circuits formed by cerebellar interneurons. Transgenic mice expressing channelrhodopsin-2 exclusively in molecular layer interneurons allowed us to focally photostimulate these neurons, while measuring resulting responses in postsynaptic Purkinje cells. This approach revealed that interneurons converge upon Purkinje cells over a broad area and that at least seven interneurons form functional synapses with a single Purkinje cell. The number of converging interneurons was reduced by treatment with gap junction blockers, revealing that electrical synapses between interneurons contribute substantially to the spatial convergence. Remarkably, gap junction blockers affected convergence in sagittal slices, but not in coronal slices, indicating a sagittal bias in electrical coupling between interneurons. We conclude that electrical synapse networks spatially coordinate interneurons in the cerebellum and may also serve this function in other brain regions.

บรรณานุกรม :
Kim, Jinsook , Lee, Soojung , Tsuda, Sachiko , Zhang, Xuying , Asrican, Brent , Gloss, Bernd , Feng, Guoping , Augustine, George J. . (2557). Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kim, Jinsook , Lee, Soojung , Tsuda, Sachiko , Zhang, Xuying , Asrican, Brent , Gloss, Bernd , Feng, Guoping , Augustine, George J. . 2557. "Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kim, Jinsook , Lee, Soojung , Tsuda, Sachiko , Zhang, Xuying , Asrican, Brent , Gloss, Bernd , Feng, Guoping , Augustine, George J. . "Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Kim, Jinsook , Lee, Soojung , Tsuda, Sachiko , Zhang, Xuying , Asrican, Brent , Gloss, Bernd , Feng, Guoping , Augustine, George J. . Optogenetic mapping of cerebellar inhibitory circuitry reveals spatially biased coordination of interneurons via electrical synapses. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.