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Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes
นักวิจัย : Lee, Wenn-Chyau , Malleret, Benoit , Lau, Yee-Ling , Mauduit, Marjorie , Fong, Mun-Yik , Cho, Jee Sun , Suwanarusk, Rossarin , Zhang, Rou , Albrecht, Letusa , Costa, Fabio T. M. , Preiser, Peter , McGready, Rose , Renia, Laurent , Nosten, Francois , Russell, Bruce
คำค้น : DRNTU::Science::Biological sciences
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Lee, W.-C., Malleret, B., Lau, Y.-L., Mauduit, M., Fong, M.-Y., Cho, J. S., et al. (2014). Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. Blood, 123(18), e100-e109. , http://hdl.handle.net/10220/19668 , http://dx.doi.org/10.1182/blood-2013-12-541698
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Blood
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Rosetting phenomenon has been linked to malaria pathogenesis. While rosetting occurs in all causes of human malaria, most data on this subject has been derived from Plasmodium falciparum. Here we investigate the function and factors affecting rosette formation in Plasmodium vivax. To achieve this, we utilised a range of novel ex vivo protocols to study fresh and cryopreserved P. vivax (n=135) and P. falciparum (n=77) isolates from Thailand. Rosetting is more common in vivax than falciparum malaria, both in terms of incidence in patient samples and percentage of infected erythrocytes forming rosettes. Rosetting to P. vivax asexual and sexual stages was evident 20 hrs post reticulocyte invasion, reaching a plateau after 30 hrs. Host ABO blood group, reticulocyte count and parasitemia were not correlated with P. vivax rosetting. Importantly, mature erythrocytes (normocytes) rather than reticulocytes preferentially form rosetting complexes, indicating this process is unlikely to directly facilitate merozoite invasion. While antibodies against host erythrocyte receptors CD235a and CD35 had no effect; Fab against the BRIC 4 region of CD236R significantly inhibited rosette formation. Rosetting assays using CD236R knock down normocytes derived from hematopoietic stem cells, further supports the role of Glycophorin C as a receptor in P. vivax rosette formation.

บรรณานุกรม :
Lee, Wenn-Chyau , Malleret, Benoit , Lau, Yee-Ling , Mauduit, Marjorie , Fong, Mun-Yik , Cho, Jee Sun , Suwanarusk, Rossarin , Zhang, Rou , Albrecht, Letusa , Costa, Fabio T. M. , Preiser, Peter , McGready, Rose , Renia, Laurent , Nosten, Francois , Russell, Bruce . (2557). Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wenn-Chyau , Malleret, Benoit , Lau, Yee-Ling , Mauduit, Marjorie , Fong, Mun-Yik , Cho, Jee Sun , Suwanarusk, Rossarin , Zhang, Rou , Albrecht, Letusa , Costa, Fabio T. M. , Preiser, Peter , McGready, Rose , Renia, Laurent , Nosten, Francois , Russell, Bruce . 2557. "Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Lee, Wenn-Chyau , Malleret, Benoit , Lau, Yee-Ling , Mauduit, Marjorie , Fong, Mun-Yik , Cho, Jee Sun , Suwanarusk, Rossarin , Zhang, Rou , Albrecht, Letusa , Costa, Fabio T. M. , Preiser, Peter , McGready, Rose , Renia, Laurent , Nosten, Francois , Russell, Bruce . "Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Lee, Wenn-Chyau , Malleret, Benoit , Lau, Yee-Ling , Mauduit, Marjorie , Fong, Mun-Yik , Cho, Jee Sun , Suwanarusk, Rossarin , Zhang, Rou , Albrecht, Letusa , Costa, Fabio T. M. , Preiser, Peter , McGready, Rose , Renia, Laurent , Nosten, Francois , Russell, Bruce . Glycophorin C (CD236R) mediates vivax malaria parasite rosetting to normocytes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.