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Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise
นักวิจัย : Catoire, Milène , Alex, Sheril , Paraskevopulos, Nicolas , Mattijssen, Frits , Gogh, Inkie Evers-van , Schaart, Gert , Jeppesen, Jacob , Kneppers, Anita , Mensink, Marco , Voshol, Peter J , Olivecrona, Gunilla , Tan, Nguan Soon , Hesselink, Matthijs K C , Berbée, Jimmy F , Rensen, Patrick C N , Kalkhoven, Eric , Schrauwen, Patrick , Kersten, Sander
คำค้น : DRNTU::Science::Biological sciences::Human anatomy and physiology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Gogh, E.-v. I., Schaart, G., et al. (2014). Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America, 111(11), E1043-E1052. , 1091-6490 , http://hdl.handle.net/10220/19418 , http://dx.doi.org/10.1073/pnas.1400889111
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Proceedings of the National Academy of Sciences of the United States of America
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Physical activity increases energy metabolism in exercising muscle. Whether acute exercise elicits metabolic changes in nonexercising muscles remains unclear. We show that one of the few genes that is more highly induced in nonexercising muscle than in exercising human muscle during acute exercise encodes angiopoietin-like 4 (ANGPTL4), an inhibitor of lipoprotein lipase-mediated plasma triglyceride clearance. Using a combination of human, animal, and in vitro data, we show that induction of ANGPTL4 in nonexercising muscle is mediated by elevated plasma free fatty acids via peroxisome proliferator-activated receptor-δ, presumably leading to reduced local uptake of plasma triglyceride-derived fatty acids and their sparing for use by exercising muscle. In contrast, the induction of ANGPTL4 in exercising muscle likely is counteracted via AMP-activated protein kinase (AMPK)-mediated down-regulation, promoting the use of plasma triglycerides as fuel for active muscles. Our data suggest that nonexercising muscle and the local regulation of ANGPTL4 via AMPK and free fatty acids have key roles in governing lipid homeostasis during exercise.

บรรณานุกรม :
Catoire, Milène , Alex, Sheril , Paraskevopulos, Nicolas , Mattijssen, Frits , Gogh, Inkie Evers-van , Schaart, Gert , Jeppesen, Jacob , Kneppers, Anita , Mensink, Marco , Voshol, Peter J , Olivecrona, Gunilla , Tan, Nguan Soon , Hesselink, Matthijs K C , Berbée, Jimmy F , Rensen, Patrick C N , Kalkhoven, Eric , Schrauwen, Patrick , Kersten, Sander . "Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.