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Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells
นักวิจัย : Chen, Qingfeng , Amaladoss, Anburaj , Ye, Weijian , Liu, Min , Dummler, Sara , Kong, Fang , Wong, Lan Hiong , Loo, Hooi Linn , Loh, Eva , Tan, Shu Qi , Tan, Thiam Chye , Chang, Kenneth T. E. , Dao, Ming , Suresh, Subra , Preiser, Peter R. , Chen, Jianzhu
คำค้น : DRNTU::Science::Biological sciences::Cytology
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Chen, Q., Amaladoss, A., Ye, W., Liu, M., Dummler, S., Kong, F., et al. (2014). Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. Proceedings of the National Academy of Sciences of the United States of America, 111(4), 1479-1484. , 1091-6490 , http://hdl.handle.net/10220/19421 , http://dx.doi.org/10.1073/pnas.1323318111
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Proceedings of the National Academy of Sciences of the United States of America
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Immunodeficient mouse–human chimeras provide a powerful approach to study host-specific pathogens, such as Plasmodium falciparum that causes human malaria. Supplementation of immunodeficient mice with human RBCs supports infection by human Plasmodium parasites, but these mice lack the human immune system. By combining human RBC supplementation and humanized mice that are optimized for human immune cell reconstitution, we have developed RBC-supplemented, immune cell-optimized humanized (RICH) mice that support multiple cycles of P. falciparum infection. Depletion of human natural killer (NK) cells, but not macrophages, in RICH mice results in a significant increase in parasitemia. Further studies in vitro show that NK cells preferentially interact with infected RBCs (iRBCs), resulting in the activation of NK cells and the elimination of iRBCs in a contact-dependent manner. We show that the adhesion molecule lymphocyte-associated antigen 1 is required for NK cell interaction with and elimination of iRBCs. Development of RICH mice and validation of P. falciparum infection should facilitate the dissection of human immune responses to malaria parasite infection and the evaluation of therapeutics and vaccines.

บรรณานุกรม :
Chen, Qingfeng , Amaladoss, Anburaj , Ye, Weijian , Liu, Min , Dummler, Sara , Kong, Fang , Wong, Lan Hiong , Loo, Hooi Linn , Loh, Eva , Tan, Shu Qi , Tan, Thiam Chye , Chang, Kenneth T. E. , Dao, Ming , Suresh, Subra , Preiser, Peter R. , Chen, Jianzhu . (2557). Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Qingfeng , Amaladoss, Anburaj , Ye, Weijian , Liu, Min , Dummler, Sara , Kong, Fang , Wong, Lan Hiong , Loo, Hooi Linn , Loh, Eva , Tan, Shu Qi , Tan, Thiam Chye , Chang, Kenneth T. E. , Dao, Ming , Suresh, Subra , Preiser, Peter R. , Chen, Jianzhu . 2557. "Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Chen, Qingfeng , Amaladoss, Anburaj , Ye, Weijian , Liu, Min , Dummler, Sara , Kong, Fang , Wong, Lan Hiong , Loo, Hooi Linn , Loh, Eva , Tan, Shu Qi , Tan, Thiam Chye , Chang, Kenneth T. E. , Dao, Ming , Suresh, Subra , Preiser, Peter R. , Chen, Jianzhu . "Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Chen, Qingfeng , Amaladoss, Anburaj , Ye, Weijian , Liu, Min , Dummler, Sara , Kong, Fang , Wong, Lan Hiong , Loo, Hooi Linn , Loh, Eva , Tan, Shu Qi , Tan, Thiam Chye , Chang, Kenneth T. E. , Dao, Ming , Suresh, Subra , Preiser, Peter R. , Chen, Jianzhu . Human natural killer cells control Plasmodium falciparum infection by eliminating infected red blood cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.