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Dengue : challenges for policy makers and vaccine developers

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Dengue : challenges for policy makers and vaccine developers
นักวิจัย : Wilder-Smith, Annelies , Macary, Paul
คำค้น : DRNTU::Science::Medicine
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Wilder-Smith, A., & Macary, P. (2014). Dengue: Challenges for Policy Makers and Vaccine Developers. Current Infectious Disease Reports, 16(5). , 1523-3847 , http://hdl.handle.net/10220/19317 , http://dx.doi.org/10.1007/s11908-014-0404-2
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Current infectious disease reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Because of the increasing incidence, geographic expansion and economic burden of dengue transmission, dengue poses major challenges to policy makers. A vaccine against dengue is urgently needed, but vaccine development has been hampered by the lack of an appropriate animal model, poor understanding of correlates of successful human immunity, the fear of immune enhancement, and viral interference in tetravalent combinations. The most suitable target epitopes for vaccines, as well as the role of nonstructural proteins remain elusive. The chimeric yellow fever bonebased live attenuated dengue vaccine is furthest in development, but initial efficacy results have been disappointing. Lessons learnt from this failure will affect the design of future trials, and increase the urgency to identify the best epitope and immune correlates. Dengue vaccine introduction will not be the only strategy to combat dengue, but needs to be “packaged” with novel vector control approaches, with community-based interventions to reduce the number of breeding sites, and reducing the case fatality rate by improving case management.

บรรณานุกรม :
Wilder-Smith, Annelies , Macary, Paul . (2557). Dengue : challenges for policy makers and vaccine developers.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Wilder-Smith, Annelies , Macary, Paul . 2557. "Dengue : challenges for policy makers and vaccine developers".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Wilder-Smith, Annelies , Macary, Paul . "Dengue : challenges for policy makers and vaccine developers."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Wilder-Smith, Annelies , Macary, Paul . Dengue : challenges for policy makers and vaccine developers. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.