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Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery
นักวิจัย : Xu, Zhigang , Wang, Dongdong , Xu, Shuang , Liu, Xiaoyan , Zhang, Xiaoyu , Zhang, Haixia
คำค้น : DRNTU::Engineering::Chemical engineering::Biochemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Xu, Z., Wang, D., Xu, S., Liu, X., Zhang, X., & Zhang, H. (2014). Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery. Chemistry - An Asian Journal, 9(1), 199-205. , 1861-4728 , http://hdl.handle.net/10220/19206 , http://dx.doi.org/10.1002/asia.201301030
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemistry - an Asian journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

We present here a novel camptothecin (CPT) prodrug based on polyethylene glycol monomethyl ether-block-poly(2-methacryl ester hydroxyethyl disulfide-graft-CPT) (MPEG-SS-PCPT). It formed biocompatible nanoparticles (NPs) with diameters of approximately 122 nm with a CPT loading content as high as approximately 25 wt % in aqueous solution. In in vitro release studies, these MPEG-SS-PCPT NPs could undergo triggered disassembly and much faster release of CPT under glutathione (GSH) stimulus than in the absence of GSH. The CPT prodrug had high antitumor activity, and another anticancer drug, doxorubicin hydrochloride (DOX⋅HCl), could also be introduced into the prodrug with a high loading amount. The DOX⋅HCl-loaded CPT prodrug could deliver two anticancer drugs at the same time to produce a collaborative cytotoxicity toward cancer cells, which suggested that this GSH-responsive NP system might become a promising carrier to improve drug-delivery efficacy.

บรรณานุกรม :
Xu, Zhigang , Wang, Dongdong , Xu, Shuang , Liu, Xiaoyan , Zhang, Xiaoyu , Zhang, Haixia . (2557). Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xu, Zhigang , Wang, Dongdong , Xu, Shuang , Liu, Xiaoyan , Zhang, Xiaoyu , Zhang, Haixia . 2557. "Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Xu, Zhigang , Wang, Dongdong , Xu, Shuang , Liu, Xiaoyan , Zhang, Xiaoyu , Zhang, Haixia . "Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Xu, Zhigang , Wang, Dongdong , Xu, Shuang , Liu, Xiaoyan , Zhang, Xiaoyu , Zhang, Haixia . Preparation of a camptothecin prodrug with glutathione-responsive disulfide linker for anticancer drug delivery. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.