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Bacteria-triggered release of antimicrobial agents

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Bacteria-triggered release of antimicrobial agents
นักวิจัย : Komnatnyy, Vitaly V. , Chiang, Wen-Chi , Tolker-Nielsen, Tim , Givskov, Michael , Nielsen, Thomas E.
คำค้น : DRNTU::Engineering::Environmental engineering
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Komnatnyy, V. V., Chiang, W. C., Tolker-Nielsen, T., Givskov, M., & Nielsen, T. E. (2014). Bacteria-Triggered Release of Antimicrobial Agents. Angewandte Chemie International Edition, 53(2), 439-441. , 1433-7851 , http://hdl.handle.net/10220/19146 , http://dx.doi.org/10.1002/anie.201307975
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Angewandte chemie international edition
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Medical devices employed in healthcare practice are often susceptible to microbial contamination. Pathogenic bacteria may attach themselves to device surfaces of catheters or implants by formation of chemically complex biofilms, which may be the direct cause of device failure. Extracellular bacterial lipases are particularly abundant at sites of infection. Herein it is shown how active or proactive compounds attached to polymeric surfaces using lipase-sensitive linkages, such as fatty acid esters or anhydrides, may be released in response to infection. Proof-of-concept of the responsive material is demonstrated by the bacteria-triggered release of antibiotics to control bacterial populations and signaling molecules to modulate quorum sensing. The self-regulating system provides the basis for the development of device-relevant polymeric materials, which only release antibiotics in dependency of the titer of bacteria surrounding the medical device.

บรรณานุกรม :
Komnatnyy, Vitaly V. , Chiang, Wen-Chi , Tolker-Nielsen, Tim , Givskov, Michael , Nielsen, Thomas E. . (2557). Bacteria-triggered release of antimicrobial agents.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Komnatnyy, Vitaly V. , Chiang, Wen-Chi , Tolker-Nielsen, Tim , Givskov, Michael , Nielsen, Thomas E. . 2557. "Bacteria-triggered release of antimicrobial agents".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Komnatnyy, Vitaly V. , Chiang, Wen-Chi , Tolker-Nielsen, Tim , Givskov, Michael , Nielsen, Thomas E. . "Bacteria-triggered release of antimicrobial agents."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Komnatnyy, Vitaly V. , Chiang, Wen-Chi , Tolker-Nielsen, Tim , Givskov, Michael , Nielsen, Thomas E. . Bacteria-triggered release of antimicrobial agents. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.