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Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts
นักวิจัย : Setyawati, Magdiel Inggrid , Khoo, Pheng Kian Stella , Eng, Bao Hui , Xiong, Sijing , Zhao, Xinxin , Das, Gautom Kumar , Tan, Timothy Thatt Yang , Loo, Joachim Say Chye , Leong, David Tai , Ng, Kee Woei
คำค้น : DRNTU::Engineering::Materials::Nanostructured materials
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2555
อ้างอิง : Setyawati, M. I., Khoo, P. K. S., Eng, B. H., Xiong, S., Zhao, X., Das, G. K., et al. (2013). Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts. Journal of Biomedical Materials Research Part A, 101A(3), 633-640. , 1549-3296 , http://hdl.handle.net/10220/19191 , http://dx.doi.org/10.1002/jbm.a.34363
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of biomedical materials research part A
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Engineered nanomaterials have become prevalent in our everyday life. While the popularity of using nanomaterials in consumer products continues to rise, increasing awareness of nanotoxicology has also fuelled efforts to accelerate our understanding of the ill effects that different nanomaterials can bring to biological systems. In this study, we investigated the potential cytotoxicity and genotoxicity of three nanoparticles: titanium dioxide (TiO2), terbium-doped gadolinium oxide (Tb-Gd2O3), and poly(lactic-co-glycolic acid) (PLGA). To evaluate nanoparticle-induced genotoxicity more realistically, a human skin fibroblast cell line (BJ) with less mutated genotype compared with cancer cell line was used. The nanoparticles were first characterized by size, morphology, and surface charge. Cytotoxicity effects of the nanoparticles were then evaluated by monitoring the proliferation of treated BJ cells. Genotoxic influence was ascertained by profiling DNA damage via detection of γH2AX expression. Our results suggested that both TiO2 and Tb-Gd2O3 nanoparticles induced cytotoxicity in a dose dependent way on BJ cells. These two nanomaterials also promoted genotoxicity via DNA damage. On the contrary, PLGA nanoparticles did not induce significant cytotoxic or genotoxic effects on BJ cells.

บรรณานุกรม :
Setyawati, Magdiel Inggrid , Khoo, Pheng Kian Stella , Eng, Bao Hui , Xiong, Sijing , Zhao, Xinxin , Das, Gautom Kumar , Tan, Timothy Thatt Yang , Loo, Joachim Say Chye , Leong, David Tai , Ng, Kee Woei . (2555). Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Setyawati, Magdiel Inggrid , Khoo, Pheng Kian Stella , Eng, Bao Hui , Xiong, Sijing , Zhao, Xinxin , Das, Gautom Kumar , Tan, Timothy Thatt Yang , Loo, Joachim Say Chye , Leong, David Tai , Ng, Kee Woei . 2555. "Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Setyawati, Magdiel Inggrid , Khoo, Pheng Kian Stella , Eng, Bao Hui , Xiong, Sijing , Zhao, Xinxin , Das, Gautom Kumar , Tan, Timothy Thatt Yang , Loo, Joachim Say Chye , Leong, David Tai , Ng, Kee Woei . "Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2555. Print.
Setyawati, Magdiel Inggrid , Khoo, Pheng Kian Stella , Eng, Bao Hui , Xiong, Sijing , Zhao, Xinxin , Das, Gautom Kumar , Tan, Timothy Thatt Yang , Loo, Joachim Say Chye , Leong, David Tai , Ng, Kee Woei . Cytotoxic and genotoxic characterization of titanium dioxide, gadolinium oxide, and poly(lactic-co-glycolic acid) nanoparticles in human fibroblasts. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2555.