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Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes
นักวิจัย : Yamakawa, Takeshi , Yoshikai, Naohiko
คำค้น : DRNTU::Science::Chemistry::Organic chemistry::Heterocyclic compounds.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Yamakawa, T., & Yoshikai, N. (2014). Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes. Chemistry - An Asian Journal, in press. , 1861-4728 , http://hdl.handle.net/10220/19125 , http://dx.doi.org/10.1002/asia.201400135
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemistry - an Asian journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

A cobalt-N-heterocyclic carbene catalyst generated from CoBr2, imidazolium salt, and cyclohexylmagnesium bromide was found to promote the imine-directed C2-alkylation of indoles with nonconjugated arylalkenes through a tandem alkene isomerization–hydroarylation process, affording 1,1-diarylalkanes with exclusive regioselectivity. The feasibility of the tandem catalysis was demonstrated for allyl-, homoallyl-, and bishomoallylbenzene derivatives. The catalytic system is also applicable to a variety of β-substituted styrene derivatives. Mechanistic experiments using deuterium-labeled indole substrate and Grignard reagent provided insight into the cobalt-mediated C[BOND]H activation step, which likely involves exchange of the C2-hydrogen atom of the former and the β-hydrogen atoms of the latter.

บรรณานุกรม :
Yamakawa, Takeshi , Yoshikai, Naohiko . (2557). Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yamakawa, Takeshi , Yoshikai, Naohiko . 2557. "Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Yamakawa, Takeshi , Yoshikai, Naohiko . "Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Yamakawa, Takeshi , Yoshikai, Naohiko . Alkene isomerization-hydroarylation tandem catalysis : indole C2-alkylation with aryl-substituted alkenes leading to 1,1-diarylalkanes. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.