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Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B
นักวิจัย : Zeng, Jing , Tan, Yu Jia , Ma, Jimei , Leow, Min Li , Tirtorahardjo, Davin , Liu, Xue-Wei
คำค้น : DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2557
อ้างอิง : Zeng, J., Tan, Y. J., Ma, J., Leow, M. L., Tirtorahardjo, D., & Liu, X.-W. (2014). Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B. Chemistry - A European Journal, 20(2), 405-409. , 0947-6539 , http://hdl.handle.net/10220/18986 , http://dx.doi.org/10.1002/chem.201303328
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Chemistry - a European journal
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

cis-2,6-Tetrahydropyran is an important structural skeleton of bioactive natural products. A facile synthesis of cis-2,6-disubstituted-3,6-dihydropyrans as cis-2,6-tetrahydropyran precursors has been achieved in high regio- and stereoselectivity with high yields. This reaction involves a palladium-catalyzed decarboxylative allylation of various 3,4-dihydro-2H-pyran substrates. Extending this reaction to 1,2-unsaturated carbohydrates allowed the achievement of challenging β-C-glycosylation. Based on this methodology, the total syntheses of (±)-centrolobine and (+)-decytospolides A and B were achieved in concise steps and overall high yields.

บรรณานุกรม :
Zeng, Jing , Tan, Yu Jia , Ma, Jimei , Leow, Min Li , Tirtorahardjo, Davin , Liu, Xue-Wei . (2557). Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zeng, Jing , Tan, Yu Jia , Ma, Jimei , Leow, Min Li , Tirtorahardjo, Davin , Liu, Xue-Wei . 2557. "Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Zeng, Jing , Tan, Yu Jia , Ma, Jimei , Leow, Min Li , Tirtorahardjo, Davin , Liu, Xue-Wei . "Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Zeng, Jing , Tan, Yu Jia , Ma, Jimei , Leow, Min Li , Tirtorahardjo, Davin , Liu, Xue-Wei . Facile access to cis-2,6-disubstituted tetrahydropyrans by palladium-catalyzed decarboxylative allylation : total syntheses of (±)-centrolobine and (+)-decytospolides A and B. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.