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Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway
นักวิจัย : Kundu, Parag , Ling, Teo Wei , Korecka, Agata , Li, Yinghui , D'Arienzo, Rossana , Bunte, Ralph M. , Berger, Thorsten , Arulampalam, Velmurugesan , Chambon, Pierre , Mak, Tak Wah , Wahli, Walter , Pettersson, Sven
คำค้น : DRNTU::Science::General.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : Monack, Denise M.
ปีพิมพ์ : 2557
อ้างอิง : Kundu, P., Ling, T. W., Korecka, A., Li, Y., D'Arienzo, R., Bunte, R. M., et al. (2014). Absence of Intestinal PPARγ Aggravates Acute Infectious Colitis in Mice through a Lipocalin-2–Dependent Pathway. PLoS Pathogens, 10(1), e1003887-. , 1553-7374 , http://hdl.handle.net/10220/18858 , http://dx.doi.org/10.1371/journal.ppat.1003887
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : PLoS pathogens
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

To be able to colonize its host, invading Salmonella enterica serovar Typhimurium must disrupt and severely affect host-microbiome homeostasis. Here we report that S. Typhimurium induces acute infectious colitis by inhibiting peroxisome proliferator-activated receptor gamma (PPARγ) expression in intestinal epithelial cells. Interestingly, this PPARγ down-regulation by S. Typhimurium is independent of TLR-4 signaling but triggers a marked elevation of host innate immune response genes, including that encoding the antimicrobial peptide lipocalin-2 (Lcn2). Accumulation of Lcn2 stabilizes the metalloproteinase MMP-9 via extracellular binding, which further aggravates the colitis. Remarkably, when exposed to S. Typhimurium, Lcn2-null mice exhibited a drastic reduction of the colitis and remained protected even at later stages of infection. Our data suggest a mechanism in which S. Typhimurium hijacks the control of host immune response genes such as those encoding PPARγ and Lcn2 to acquire residence in a host, which by evolution has established a symbiotic relation with its microbiome community to prevent pathogen invasion.

บรรณานุกรม :
Kundu, Parag , Ling, Teo Wei , Korecka, Agata , Li, Yinghui , D'Arienzo, Rossana , Bunte, Ralph M. , Berger, Thorsten , Arulampalam, Velmurugesan , Chambon, Pierre , Mak, Tak Wah , Wahli, Walter , Pettersson, Sven . (2557). Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kundu, Parag , Ling, Teo Wei , Korecka, Agata , Li, Yinghui , D'Arienzo, Rossana , Bunte, Ralph M. , Berger, Thorsten , Arulampalam, Velmurugesan , Chambon, Pierre , Mak, Tak Wah , Wahli, Walter , Pettersson, Sven . 2557. "Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kundu, Parag , Ling, Teo Wei , Korecka, Agata , Li, Yinghui , D'Arienzo, Rossana , Bunte, Ralph M. , Berger, Thorsten , Arulampalam, Velmurugesan , Chambon, Pierre , Mak, Tak Wah , Wahli, Walter , Pettersson, Sven . "Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2557. Print.
Kundu, Parag , Ling, Teo Wei , Korecka, Agata , Li, Yinghui , D'Arienzo, Rossana , Bunte, Ralph M. , Berger, Thorsten , Arulampalam, Velmurugesan , Chambon, Pierre , Mak, Tak Wah , Wahli, Walter , Pettersson, Sven . Absence of intestinal PPARγ aggravates acute infectious colitis in mice through a Lipocalin-2–dependent pathway. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2557.