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The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids
นักวิจัย : Ding, Jun , Loizides-Mangold, Ursula , Rando, Gianpaolo , Zoete, Vincent , Michielin, Olivier , Reddy, Janardan K. , Wahli, Walter , Riezman, Howard , Thorens, Bernard
คำค้น : DRNTU::Science::Medicine.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Ding, J., Loizides-Mangold, U., Rando, G., Zoete, V., Michielin, O., Reddy, J. K., et al. (2013). The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids. Cell reports, 5(1), 248-258. , 2211-1247 , http://hdl.handle.net/10220/18745 , http://dx.doi.org/10.1016/j.celrep.2013.08.032
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Cell reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Specific metabolic pathways are activated by different nutrients to adapt the organism to available resources. Although essential, these mechanisms are incompletely defined. Here, we report that medium-chain fatty acids contained in coconut oil, a major source of dietary fat, induce the liver ω-oxidation genes Cyp4a10 and Cyp4a14 to increase the production of dicarboxylic fatty acids. Furthermore, these activate all ω- and β-oxidation pathways through peroxisome proliferator activated receptor (PPAR) α and PPARγ, an activation loop normally kept under control by dicarboxylic fatty acid degradation by the peroxisomal enzyme L-PBE. Indeed, L-pbe−/− mice fed coconut oil overaccumulate dicarboxylic fatty acids, which activate all fatty acid oxidation pathways and lead to liver inflammation, fibrosis, and death. Thus, the correct homeostasis of dicarboxylic fatty acids is a means to regulate the efficient utilization of ingested medium-chain fatty acids, and its deregulation exemplifies the intricate relationship between impaired metabolism and inflammation.

บรรณานุกรม :
Ding, Jun , Loizides-Mangold, Ursula , Rando, Gianpaolo , Zoete, Vincent , Michielin, Olivier , Reddy, Janardan K. , Wahli, Walter , Riezman, Howard , Thorens, Bernard . (2556). The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ding, Jun , Loizides-Mangold, Ursula , Rando, Gianpaolo , Zoete, Vincent , Michielin, Olivier , Reddy, Janardan K. , Wahli, Walter , Riezman, Howard , Thorens, Bernard . 2556. "The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Ding, Jun , Loizides-Mangold, Ursula , Rando, Gianpaolo , Zoete, Vincent , Michielin, Olivier , Reddy, Janardan K. , Wahli, Walter , Riezman, Howard , Thorens, Bernard . "The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Ding, Jun , Loizides-Mangold, Ursula , Rando, Gianpaolo , Zoete, Vincent , Michielin, Olivier , Reddy, Janardan K. , Wahli, Walter , Riezman, Howard , Thorens, Bernard . The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain Fatty acids. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.