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Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells
นักวิจัย : Tan, Aaron , Farhatnia, Yasmin , Goh, Debbie , G, Natasha , de Mel, Achala , Lim, Jing , Teoh, Swee-Hin , Malkovskiy, Andrey V. , Chawla, Reema , Rajadas, Jayakumar , Cousins, Brian G. , Hamblin, Michael R. , Alavijeh, Mohammad S. , Seifalian, Alexander M.
คำค้น : DRNTU::Engineering::Chemical engineering::Biochemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Tan, A., Farhatnia, Y., Goh, D., G, N., de Mel, A., Lim, J., et al. (2013). Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells. Biointerphases, 8(1), 23-40. , 1559-4106 , http://hdl.handle.net/10220/18652 , http://dx.doi.org/10.1186/1559-4106-8-23
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Biointerphases
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

An unmet need exists for the development of next-generation multifunctional nanocomposite materials for biomedical applications, particularly in the field of cardiovascular regenerative biology. Herein, we describe the preparation and characterization of a novel polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer with covalently attached anti-CD34 antibodies to enhance capture of circulating endothelial progenitor cells (EPC). This material may be used as a new coating for bare metal stents used after balloon angioplasty to improve re-endothelialization. Biophysical characterization techniques were used to assess POSS-PCU and its subsequent functionalization with anti-CD34 antibodies. Results indicated successful covalent attachment of anti-CD34 antibodies on the surface of POSS-PCU leading to an increased propensity for EPC capture, whilst maintaining in vitro biocompatibility and hemocompatibility. POSS-PCU has already been used in 3 first-in-man studies, as a bypass graft, lacrimal duct and a bioartificial trachea. We therefore postulate that its superior biocompatibility and unique biophysical properties would render it an ideal candidate for coating medical devices, with stents as a prime example. Taken together, anti-CD34 functionalized POSS-PCU could form the basis of a nano-inspired polymer platform for the next generation stent coatings.

บรรณานุกรม :
Tan, Aaron , Farhatnia, Yasmin , Goh, Debbie , G, Natasha , de Mel, Achala , Lim, Jing , Teoh, Swee-Hin , Malkovskiy, Andrey V. , Chawla, Reema , Rajadas, Jayakumar , Cousins, Brian G. , Hamblin, Michael R. , Alavijeh, Mohammad S. , Seifalian, Alexander M. . (2556). Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Aaron , Farhatnia, Yasmin , Goh, Debbie , G, Natasha , de Mel, Achala , Lim, Jing , Teoh, Swee-Hin , Malkovskiy, Andrey V. , Chawla, Reema , Rajadas, Jayakumar , Cousins, Brian G. , Hamblin, Michael R. , Alavijeh, Mohammad S. , Seifalian, Alexander M. . 2556. "Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Tan, Aaron , Farhatnia, Yasmin , Goh, Debbie , G, Natasha , de Mel, Achala , Lim, Jing , Teoh, Swee-Hin , Malkovskiy, Andrey V. , Chawla, Reema , Rajadas, Jayakumar , Cousins, Brian G. , Hamblin, Michael R. , Alavijeh, Mohammad S. , Seifalian, Alexander M. . "Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Tan, Aaron , Farhatnia, Yasmin , Goh, Debbie , G, Natasha , de Mel, Achala , Lim, Jing , Teoh, Swee-Hin , Malkovskiy, Andrey V. , Chawla, Reema , Rajadas, Jayakumar , Cousins, Brian G. , Hamblin, Michael R. , Alavijeh, Mohammad S. , Seifalian, Alexander M. . Surface modification of a polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU) nanocomposite polymer as a stent coating for enhanced capture of endothelial progenitor cells. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.