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Comparative study of label-free electrochemical immunoassay on various gold nanostructures.

หน่วยงาน Nanyang Technological University, Singapore

รายละเอียด

ชื่อเรื่อง : Comparative study of label-free electrochemical immunoassay on various gold nanostructures.
นักวิจัย : Rafique, S. , Gao, C. , Li, C. M. , Bhatti, A. S.
คำค้น : DRNTU::Engineering::Chemical engineering.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Rafique, S., Gao, C., Li, C. M., & Bhatti, A. S. (2013). Comparative study of label-free electrochemical immunoassay on various gold nanostructures. Journal of applied physics, 114(16), 164703-. , 0021-8979 , http://hdl.handle.net/10220/18436 , http://dx.doi.org/10.1063/1.4827381
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Journal of applied physics
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

Electrochemical methods such as amperometry and impedance spectroscopy provide the feasibility of label-free immunoassay. However, the performance of electrochemical interfaces varies with the shape of gold nanostructures. In the present work three types of gold nanostructures including pyramid, spherical, and rod-like nanostructures were electrochemically synthesized on the gold electrode and were further transformed into immunosensor by covalent binding of antibodies. As a model protein, a cancer biomarker, Carcinoembryonic Antigen (CEA) was detected using amperometric and impedimetric techniques on three nanostructured electrodes, which enabled to evaluate and compare the immunoassay's performance. It was found that all three immunosensors showed improved linear electrochemical response to the concentration of CEA compared to bare Au electrode. Among all the spherical gold nanostructure based immunosensors displayed superior performance. Under optimal condition, the immunosensors exhibited a limit of detection of 4.1 pg ml−1 over a concentration range of five orders of magnitude. This paper emphasizes that fine control over the geometry of nanostructures is essentially important for high-performance electrochemical immunoassay.

บรรณานุกรม :
Rafique, S. , Gao, C. , Li, C. M. , Bhatti, A. S. . (2556). Comparative study of label-free electrochemical immunoassay on various gold nanostructures..
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Rafique, S. , Gao, C. , Li, C. M. , Bhatti, A. S. . 2556. "Comparative study of label-free electrochemical immunoassay on various gold nanostructures.".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Rafique, S. , Gao, C. , Li, C. M. , Bhatti, A. S. . "Comparative study of label-free electrochemical immunoassay on various gold nanostructures.."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Rafique, S. , Gao, C. , Li, C. M. , Bhatti, A. S. . Comparative study of label-free electrochemical immunoassay on various gold nanostructures.. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.