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Functional role of the flexible N-terminal extension of FKBP38 in catalysis

หน่วยงาน Nanyang Technological University, Singapore

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ชื่อเรื่อง : Functional role of the flexible N-terminal extension of FKBP38 in catalysis
นักวิจัย : Kang, CongBao , Ye, Hong , Chia, Joel , Choi, Bo-Hwa , Dhe-Paganon, Sirano , Simon, Bernd , Schütz, Ulrike , Sattler, Michael , Yoon, Ho Sup
คำค้น : DRNTU::Science::Biological sciences.
หน่วยงาน : Nanyang Technological University, Singapore
ผู้ร่วมงาน : -
ปีพิมพ์ : 2556
อ้างอิง : Kang, C., Ye, H., Chia, J., Choi, B.-H., Dhe-Paganon, S., Simon, B., et al. (2013). Functional role of the flexible N-terminal extension of FKBP38 in catalysis. Scientific reports, 3, 1-8. , 2045-2322 , http://hdl.handle.net/10220/18389 , http://dx.doi.org/10.1038/srep02985
ที่มา : -
ความเชี่ยวชาญ : -
ความสัมพันธ์ : Scientific reports
ขอบเขตของเนื้อหา : -
บทคัดย่อ/คำอธิบาย :

FKBP38 regulates apoptosis through unique interactions with multiple regulators including Bcl-2. Interestingly, the peptidylprolyl isomerase activity of FKBP38 is only detectable when it binds to calcium-saturated calmodulin (CaM/Ca2+). This, in turn, permits the formation of a complex with Bcl-2. FKBP38 thereby provides an important link between isomerase activity and apoptotic pathways. Here, we show that the N-terminal extension (residues 1-32) preceding the catalytic domain of FKBP38 has an autoinhibitory activity. The core isomerase activity of FKBP38 is inhibited by transient interactions involving the flexible N-terminal extension that precedes the catalytic domain. Notably, CaM/Ca2+ binds to this N-terminal extension and thereby releases the autoinhibitory contacts between the N-terminal extension and the catalytic domain, thus potentiating the isomerase activity of FKBP38. Our data demonstrate how CaM/Ca2+ modulates the catalytic activity of FKBP38.

บรรณานุกรม :
Kang, CongBao , Ye, Hong , Chia, Joel , Choi, Bo-Hwa , Dhe-Paganon, Sirano , Simon, Bernd , Schütz, Ulrike , Sattler, Michael , Yoon, Ho Sup . (2556). Functional role of the flexible N-terminal extension of FKBP38 in catalysis.
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kang, CongBao , Ye, Hong , Chia, Joel , Choi, Bo-Hwa , Dhe-Paganon, Sirano , Simon, Bernd , Schütz, Ulrike , Sattler, Michael , Yoon, Ho Sup . 2556. "Functional role of the flexible N-terminal extension of FKBP38 in catalysis".
    กรุงเทพมหานคร : Nanyang Technological University, Singapore.
Kang, CongBao , Ye, Hong , Chia, Joel , Choi, Bo-Hwa , Dhe-Paganon, Sirano , Simon, Bernd , Schütz, Ulrike , Sattler, Michael , Yoon, Ho Sup . "Functional role of the flexible N-terminal extension of FKBP38 in catalysis."
    กรุงเทพมหานคร : Nanyang Technological University, Singapore, 2556. Print.
Kang, CongBao , Ye, Hong , Chia, Joel , Choi, Bo-Hwa , Dhe-Paganon, Sirano , Simon, Bernd , Schütz, Ulrike , Sattler, Michael , Yoon, Ho Sup . Functional role of the flexible N-terminal extension of FKBP38 in catalysis. กรุงเทพมหานคร : Nanyang Technological University, Singapore; 2556.